Pharmacology: Drug Actions and ReactionsCompletely revised and updated, this is the seventh edition of Levine's classic pharmacology textbook. Known for it's thorough coverage and intelligent organization, the book covers the basic principles of pharmacological interactions on the human body in a way that is useful for both undergraduate and graduate students. Beginning with historical perspectives, nomenclature and definitions, the topics broaden to include sites and mechanisms of drug actions and travel to sites of action, as well as termination and elimination. The book also includes drug response and time-response relationships, response variability, drug toxicity, drug abuse, drug dependence, and more. |
Contents
Chapter 1 The Heritage of Pharmacology | 1 |
Chapter 2 The Scope of Pharmacology | 18 |
Chapter 3 How Drugs Act on the Living Organism | 27 |
Chapter 4 How Drugs Reach Their Site of Action | 53 |
Chapter 5 How Drugs Reach Their Site of Action | 77 |
Chapter 6 How Drugs Reach Their Site of Action | 111 |
Chapter 7 How the Actions of Drugs are Terminated | 128 |
Chapter 8 How the Actions of Drugs are Terminated | 153 |
Chapter 11 Factors Modifying the Effects of Drugs in Individuals | 266 |
Chapter 12 Factors Modifying the Effects of Drugs in Individuals | 294 |
Chapter 13 Drug Toxicity | 329 |
Chapter 14 How Drugs Alter Physiologic Function | 369 |
Chapter 15 The Pharmacologic Aspects of Drug Abuse | 392 |
Chapter 16 The Development and Evaluation of New Drugs | 427 |
Glossary | 454 |
Appendixes | 472 |
Chapter 9 General Principles of the Quantitative Aspects of Drug Action | 186 |
Chapter 10 General Principles of the Quantitative Aspects of Drug Action | 225 |
Back Cover | 577 |
Common terms and phrases
acetylcholine acid active transport administration agonist alcohol allergic amount of drug amphetamine analgesic anesthetics animals antagonism antagonist aspirin atropine barbiturates benzodiazepines binding biologic barriers biotransformation blood body brain capillary cells chemical clinical compounds concentration conjugation decrease dependence depression determined diffusion disease distribution dosage dose dose-effect curves drug action duration of action elimination elimination half-life enzyme ethanol example excretion factors fluid function gastric gastrointestinal gastrointestinal tract glomerulus humans increase individual inhibit inhibitors injection interaction intestine intravenous ionic bond kidney levels lipid liver loop of Henle mechanism of action membrane metabolism metabolites molecules morphine muscle nerve nervous system neurons norepinephrine normal opioid oral organs patients penicillin pharmacologic phenobarbital physiologic plasma poisoning produce protein rate of absorption reabsorption reactions receptor renal renal plasma clearance response route side-effects solubility solute specific stimulation structure substances substrate therapy tissue tolerance toxic effects treatment tubular tubule urine