Pharmacology of the SkinThis book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development. |
Contents
Percutaneous Absorption | 14 |
Mechanisms of Percutaneous Absorption | 19 |
Acknowledgments | 25 |
Copyright | |
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Acad activity adhesion agents allergic antibodies antioxidant Bickers binding Biochem Biol biological Biophys calcium carcinogenesis carcinogens carcinomas cellular Chem chemical Clin clinical compounds cultured cutaneous cytochrome P-450 cytokines dermal Dermatol dermis differentiation diseases dose effects enzyme epidermal epidermal cells exposure fibroblasts free radicals function gene glutathione growth factor hormone human epidermis human keratinocytes human skin ICAM-1 expression Immunol increased induced inflammatory inhibition inhibitor inositol interleukin-1 Invest isotretinoin isozymes keratinocytes Langerhans cells lipid liver lymphocytes mediated melanoma membrane metabolites mice microsomes molecular molecules mouse skin mRNA Mukhtar murine Natl normal nude oxygen pathway patients percutaneous absorption Pharmacol phorbol ester photosensitization Proc production proliferation protein kinase psoralen psoriasis psoriatic reactions reactive regulation response retinoic acid retinoids role specific stimulating stratum corneum studies substrate sunscreens synthesis testosterone therapy tissue topical application transdermal tumor promotion UV radiation vitamin vitamin D vitro vivo