Pharmacotherapy of Obesity

Front Cover
John P. H. Wilding
Springer Science & Business Media, Jan 8, 2008 - Medical - 120 pages
2 Reviews

Obesity has become a major epidemic that now rivals smoking as a risk to public health. The ensuing epidemics of diabetes, vascular disease and other complications are set to overwhelm the healthcare systems of wealthy and poorer nations alike. The need for effective pharmacotherapy has never been greater. This book takes a new look at the many potential targets for drug development for regulation of body weight, placing them in the context of the chequered history of drug development for obesity and currently available therapies.

Potential peripheral and central nervous system targets are discussed in detail by authors with extensive knowledge and research experience in the science of body weight regulation, and its translation into effective therapies that will benefit patients. This book is of interest to clinicians, researchers in the field and members of the pharmaceutical industry who are interested in learning more about the current state of the art and future directions in the pharmacotherapy of obesity.

 

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Contents

Why drugs?
1
Some historical aspects of drug treatment for obesity
11
Regulation of energy balance towards rational drug design in obesity
21
Intestinal lipase inhibitors
47
Sibutramine
59
The endocannabinoid system as a target for obesity treatment
69
Using the bodys natural signals gut hormones
81
Influencing energy expenditure and substrate utilisation
101
Index
117
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