Philosophy of Stem Cell Biology: Knowledge in Flesh and Blood
This examination of stem cell biology from a philosophy of science perspective clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. Relations to systems biology and clinical medicine are also discussed.
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abstract model adult stem cell biologists blood cell bone marrow cancer causal relations cell development cell division cell division events cell populations cell types cellular Chapter character values clinical complex components context core developmental potential difference-makers differentiation potential diverse DNA sequences embryonic stem cells environment epistemic evidential experimental biology explanatory Figure gene expression genetic germ layers hESC human hypotheses interactions iPSC laboratory landscape model manipulability measured mechanistic explanation ment mice model organisms molecular mechanisms mouse organismal source phenomena philosophy of science PI-specificity pluripotency research pluripotent stem cells predictions proteins represent representational assumptions Rijswijk robust role self-renewal and differentiation single cells single-cell specific stem cell biology stem cell capacities stem cell concept stem cell experiments stem cell lines stem cell model stem cell research stemness account structure systems biology teratocarcinoma theory tion tissue tissue-specific traits unified variable Waddington’s landscape Zipori