Physicochemical Basis of Pharmaceuticals

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OUP Oxford, Jul 23, 2009 - Business & Economics - 296 pages
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What are the physical and chemical properties that determine how a drug interacts with the body? What determines which dosage form is best, if it will reach its intended target, and how it will be metabolised once it has entered the body? The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these concepts apply in practice. The book introduces key underlying physical chemistry principles before exploring pharmaceutical solutions, the pharmaceutical solid phase, solid - liquid dispersal systems, biological interfaces, absorption, distribution, metabolism and excretion, to give a complete view of the field. Focusing at all times on the essential principles and concepts, The Physicochemical Basis of Pharmaceuticals avoids excessive detail, presenting the key facts, backed up with pertinent examples and easy-to-digest illustrations, making it the ideal primer for those who need to understand physicochemical issues in the context of their broader field of study. Online Resource Centre For registered adopters of the text: ˇ Figures from the book in electronic format, ready to download For students: ˇ A hyperlinked bibliography of references given in the text.
 

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Contents

1 PHARMACEUTICALS AND MEDICINES
1
2 PHARMACEUTICAL SOLUTIONS
22
3 PHARMACEUTICAL EQUILIBRIA
56
4 THE PHARMACEUTICAL SOLID PHASE
106
5 THE THEORY OF DISPERSE SYSTEMS
156
6 PHARMACEUTICAL DISPERSE SYSTEMS
193
7 DRUG PARTITIONING AND TRANSPORT ACROSS BIOLOGICAL BARRIERS
212
8 PHYSICOCHEMICAL ASPECTS OF PHARMACOKINETICS
255
A1 COMPREHENSIVE LIST OF ROUTES OF ADMINISTRATION
278
A2 BRIEF REVIEW OF LOGARITHMS
280
A3 ACTIVITIES OF IONS IN SOLUTION
281
A4 OSMOTIC PRESSURE
284
A5 SOLUTIONS TO END OF CHAPTER EXERCISES
286
GLOSSARY
288
INDEX
290
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About the author (2009)

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Having originally received his BSc and PhD degrees from University College Cork, Humphrey Moynihan returned in 2002, where he is now involved in the teaching of Organic and Pharmaceutical/Medicinal Chemistry. His research interest is the study and control of crystallisation of organic compounds. He is also involved in collaborative research in areas such as Analytical Chemistry.

Abina Crean joined the Cork School of Pharmacy in September 2004 as a Lecturer in Pharmaceutics after working in formulation and process development for Élan Pharmaceutical Technologies and Servier (Ireland) Industries.
Her main research interests are in the areas of solid dose drug delivery systems and pharmaceutical solid-state properties.

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