Physicochemical Principles of Pharmacy
This book provides the physicochemical background to the design and use of pharmaceutical dosage forms. It goes beyond the introductory aspects of the subject to show how basic physicochemical principles are essential to an understanding of every aspect of drug action, from the dosage form to the site of action in the body. This is not a textbook of physical chemistry for pharmacists, but is a book which bridges the gap between basic first-year physical chemistry and the more applied practice of later years. This extensively revised second edition includes much new material, illustrations and references to take into account recent scientific developments and curriculum changes.
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Properties of the Solid State
Physicochemical Properties of Drugs in Solution
Chemical Stability of Drugs
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absorption acetate acid activity adhesion adsorbed adsorption aerosol agents anionic antacid aqueous phase aqueous solution base betamethasone blood buffer calculated cationic cells cent chains chemical chemical potential chloride colloidal complex component compounds concentration crystal crystalline decomposition decrease diffusion digoxin dilute dispersed dissolution dosage forms dose drug effect electrolytes emulsifiers emulsions equation equilibrium example film flocculation fluid formulation glycol griseofulvin groups hydration hydrolysis hydrophilic hydrophobic increase injection insulin interaction interface intestine ionic ionisation ions layer lipid lipophilic liquid macromolecules membrane micellar micelle mixture mole molecular weight molecules non-ionic osmotic particles partition coefficient permeability pharm pharmaceutical phenobarbitone pilocarpine plasma plot polymer polymorphic polyoxyethylene Polysorbate Polysorbate 80 properties protein binding rate constant reaction reduced reference resin salt sodium solid solubilisation solubility solvent stability steroids structure substance sulphonamides surface surfactants suspension tablet temperature tetracycline tion unionised values vapour pressure viscosity Warfarin