Physiology and Physiopathology of Adipose Tissue
Jean-Philippe Bastard, Bruno Fève
Springer Science & Business Media, Nov 28, 2012 - Medical - 440 pages
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
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activity adipocyte differentiation adipocytes adipogenesis adipokines adiponectin angiogenesis apelin ASCs associated binding Biol Chem body fat brown adipocytes cellular Clin clinical cytokines decrease diet diet-induced disease ectopic effects Endocrinol Metab endothelial cells energy enzymes fat cell fat depots fat mass fatty acids France function gene expression genetic glucose transport Glut4 hepatic hormone human adipose tissue increased induced inflammation inflammatory inhibition INSERM insulin receptor insulin resistance insulin sensitivity insulin signaling interaction intracellular involved kinase leptin levels lipase lipid droplet lipodystrophy lipolysis lipolytic lipoprotein liver macrophages markers mechanisms metabolic syndrome mice mitochondrial molecular molecules mouse mRNA mutations Nutrition obese subjects obesity oxidation patients perilipin phenotype phosphorylation Physiol plasma membrane PPARc preadipocytes protein regulation resistin rodents role secretion signaling pathway stem cells stimulation storage studies subcutaneous synthesis target transcription factor triglyceride type 2 diabetes UCP1 uptake visceral fat visfatin vitro vivo weight loss white adipose tissue