Physiology and pharmacology of the blood-brain barrier
N. Joan Abbott, Michael William Blackburn Bradbury
Springer-Verlag, 1992 - Medical - 549 pages
The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!
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abluminal activity albumin amino acid transport amino acids arterial astrocytes BBB disruption Betz binding Biol Blood Flow Metab blood-brain barrier permeability blood-brain glucose transfer bolus Bradbury brain capillary brain endothelium brain microvessels brain perfusion Brain Res brain uptake Bundgaard capillary capillary endothelium cellular central nervous system Cereb Blood Flow cerebral capillary cerebral endothelium cerebrospinal fluid choroid plexus concentration Crone Cserr diffusion drug effect endothelial cells endothelium enzyme experimental extracellular Gjedde glial glucose transport Greig human increase infusion inhibition injection insulin interstitial fluid intravenous isolated kinetics leucine levels luminal mannitol measured mechanism membrane metabolism method molecules Neurochem Neurol neutral amino acid Neuwelt normal Oldendorf osmotic Pardridge WM patients peptide perfusion perivascular Physiol Lond plasma plasma proteins positron emission tomography protein Rapoport rat brain receptors regions serum studies surface technique tight junctions tissue tracer transferrin tryptophan unidirectional vascular vessels vitamin vitro vivo Zlokovic