Physiology, Biochemistry, and Molecular Biology of the Skin, Volume 1
Lowell A. Goldsmith
Oxford University Press, 1991 - Science - 1529 pages
There have been rapid advances in the molecular biology of the skin since the first appearance of this acclaimed work. The genes for several of the structural and regulatory proteins in the epidermis and dermis have been cloned and their regulation is being characterized. Understanding the skin at the genetic level has yielded new insights into skin physiology and these are presented in the Second Edition. The section on the immune system, both its afferent arm including the Langerhans cell, and its efferent functions including the interleukins, has been greatly expanded. A new section on the neurobiology of skin discusses cell-to-cell communication and the expanded role of the Merkel cell, among other topics. Growth factors have increasing significance in normal control of skin growth, psoriasis, and neoplasia; these factors and their implications are discussed extensively in the new edition. Like the first edition, this book is rich in data, profusely illustrated with light and electron micrographs, and heavily referenced. It is the first choice as a reference work for skin researchers throughout the world and the prime source for basic science education of dermatologists and dermatology trainees.
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Nonionizing Radiation and ROBERT E TIGELAAR
Reactions in the Skin JOHN R STANLEY
Nutritional Influences on JAMES J LEY
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Acad amino acid antibody antigen arachidonic acid basal cells basal layer binding Biochem Biophys calcium calmodulin Cell Biol cell cycle cell envelope cell types cellular chain Chem collagen cornified cross-linked cytoplasmic dermal Dermatol Dermatology dermis domain EGF receptor EGF/TGF-a enzyme epider epidermal cells epidermal growth factor epidermal transglutaminase expression fatty acids fetal fibroblasts filaggrin formation function gland growth factor receptor Holbrook human epidermis human keratinocytes human skin increase inhibition interactions intermediate filaments intracellular Invest involucrin keratin keratinocytes kinase activity kinetics labeling lipids membrane metabolism molecular molecules mouse mRNA Natl Nature London normal PDGF peptide periderm phorbol ester phospholipase phosphorylation precursor Proc profilaggrin proliferative protein kinase psoriasis psoriatic regulation residues retinoic acid retinoids retinol role sequence Steinert stimulates stratum corneum structure studies substrate synthesis terminal differentiation TGF-a tion tissue transforming growth transglutaminase activity tumor tyrosine kinase vitro vivo Wertz Yuspa