Physiology of Respiration
This concise, lucid textbook provides a basis for understanding the function of the respiratory system and a framework for the treatment of many respiratory diseases. It was developed as a working text with problem-solving exercises for the student's use in reviewing each chapter. The writing style flows easily from one topic to another. Mathematical relationships are presented in a simple way and are clearly explained. The illustrations are carefully designed to convey ideas in an easy-to-understand format. The book's scope is comprehensive, encompassing all aspects of respiratory physiology, including pulmonary anatomy and microstructure, mechanics, gas exchange, acid-base balance and control mechanisms. Unlike many texts, this one strikes a good balance between the principles of pulmonary gas exchange (ventilation, perfusion, gas exchange efficiency) and the neural control of respiration (central and chemical mechanisms and reflexes). It emphasizes integrative aspects of respiration such as the system's response to altitude, hyperbaric environments, exercise, sleep, and the in utero and early postnatal period. The second edition has been reorganized to make the book more approachable by students, and it has been updated throughout, including many new ideas about the distribution of lung blood flow and respiratory rhythm generation.
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Overview and Physical Principles
Functional Pulmonary Anatomy
Mechanics of Ventilation
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40 mm Hg acid—base acidosis activity Adapted alveolar gas alveolar pressure alveolar ventilation alveoli apnea arterial blood bicarbonate breathing bronchial bubble buffer value C-fiber capillary cardiac output carotid bodies causes cells central chemosensors changes Chapter chemosensors chest wall circulation cm H2O concentration dead space decrease diffusing capacity disease effect equation equilibrium curve exercise exhaled expiration fetal fibers Figure fluid function gas exchange gases hemoglobin hydrogen ion hypoxemia hypoxia hypoxic increase inflation inspired intercostal lung volume mechanisms membrane metabolic metabolic acidosis mixed ml dl molecules motoneurons nerve neurons normal NREM occurs Oxygen PA.co Paco partial pressure perfusion phrenic Physiol pleural pulmonary blood flow pulmonary capillary receptors recoil pressure reduced reflex relationship respiration respiratory muscles respiratory physiology respiratory system sensory shunt solubility surface surfactant tidal volume tissue trachea upper airway VA/Q vascular venous ventilatory response vessels