Plasminogen: Structure, Activation, and Regulation: Structure, Activation, and Regulation

Front Cover
Springer Science & Business Media, Aug 31, 2003 - Medical - 293 pages
0 Reviews
inthisresearchfieldandthemanyexcitingdiscoveriessuggeststhattheresearchefforts inthenextdecadewillrevealthemechanismsbywhichthecomponentsoftheplas­ minogensysteminteractandregulatebothplasminactivationandfunctionatacellular level. Plasminogen: Structure, activation, and regulationisdividedintotwosections. Thefirstsectiondealswiththestructureandregulationofplasminogen. Thechapters inthissectionrangefromdiscussionsofthestructureofplasminogenandtheregulation oftheplasminogengenetodiscussionsofthestructureandregulationofplasminogen activatorsandplasminogenactivatorinhibitors. Alsoexaminedistherelativelynewdata concerningthegenerationofanti-angiogenicmoleculesfromplasminogen. Thesecond sectiondealswiththephysiologicalandpathophysiologicalrolesofplasminogenaswell astheconsequencesofplasminogengeneknockout. Discussionsinthissectioninclude examinationoftheroleofplasminogeninhematopoieticmalignancies,tumorcell progression,angiogenesis,mammaryglandinvolution,woundhealing,andbone readsorption. xi xii Preface Inclosing,Iwouldliketothankmyadministrativeassistant,Ms. ViSommerfeld,for herinvaluableassistanceandtimelesseffortswiththeorganizationandeditingofthebook. Lastly,Iwouldliketoacknowledgetheeffortsoftheauthorsoftheindividualchapters, whoareauthorities inthisfield,foragreeingtotaketimefrombusyschedulestoprovide thesechaptersinatimelyfashion. DavidMortonWaisman Contents Part I. Plasminogen: Structure and Regulation 1. Human Plasminogen: Structure, Activation, and Function FrancisJ. Castellino and Victoria A. Ploplis 1. Introduction 3 2. StructureofHumanPlasminogen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. PrimaryProteinStructure. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. GeneOrganization 5 3. ActivationofHumanPlasminogen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 3. 1. ActivationbyPhysiologicalActivators 7 3. 1. 1. Urokinase-typePlasminogenActivator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. 2. Tissue-typePlasminogenActivator. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2. ActivationbyBacterial-derivedPlasminogenActivators. . . . . . . . . . . . . . . . . . . . . 9 3. 2. 1. Streptokinase 9 3. 2. 2. Staphylokinase. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 4. TargetsforPlasminActivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 5. DysplasminogenemiasandPhenotypicManifestations 10 6. Conclusions 11 References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 2. Plasminogen Activators: Structure and Function Vincent Ellis 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 2. SerineProteases. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 3. UrokinasePlasminogenActivator,uPA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 3. 1. SerineProteaseDomain 22 3. 2. N-terminalDomains. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 3. 2. 1. KRModule 24 3. 2. 2. EGModule 24 4. MechanismsRegulatinguPAFunction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4. 1. ZymogenActivation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 4. 2. ZymogenActivity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 4. 3. ReciprocalZymogenActivation 27 4. 4. uPARStimulationofPlasminogenActivation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 4. 4. 1. uPAandtheTemplateMechanism 28 4. 4. 2. PlasminogenandtheTemplateMechanism 29 4. 5. AvianuPA,aSpecialCase? 30 xiii xi
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

III
3
VII
5
VIII
6
IX
7
X
8
XI
9
XIV
10
XV
11
CXXIV
157
CXXV
159
CXXIX
160
CXXX
161
CXXXI
163
CXXXIII
164
CXXXIV
165
CXXXVI
166

XVII
19
XVIII
20
XIX
21
XX
22
XXI
24
XXIV
25
XXV
26
XXVI
27
XXVIII
28
XXIX
29
XXX
30
XXXII
31
XXXIII
33
XXXV
34
XXXVI
35
XXXVII
36
XXXVIII
37
XL
38
XLIII
39
XLIV
40
XLV
47
XLVI
48
XLVII
49
XLVIII
50
XLIX
51
L
52
LI
53
LII
54
LIV
55
LV
56
LVIII
57
LIX
67
LXII
68
LXV
72
LXVII
74
LXVIII
75
LXIX
76
LXXI
77
LXXIII
78
LXXV
81
LXXVIII
82
LXXIX
83
LXXX
85
LXXXI
86
LXXXIII
87
LXXXV
88
LXXXVII
91
LXXXVIII
97
LXXXIX
98
XC
103
XCIII
104
XCIV
106
XCV
107
XCVI
112
XCVII
114
XCVIII
115
XCIX
116
CI
121
CIII
122
CIV
124
CV
125
CVI
126
CVIII
128
CIX
129
CX
131
CXII
135
CXIII
136
CXIV
139
CXV
140
CXVI
141
CXVII
143
CXIX
146
CXX
148
CXXI
151
CXXXVII
167
CXXXVIII
168
CXXXIX
170
CXL
171
CXLII
177
CXLIII
178
CXLIV
179
CXLVI
181
CXLVIII
182
CL
183
CLII
184
CLIV
189
CLV
191
CLVII
192
CLVIII
193
CLIX
194
CLX
195
CLXII
196
CLXV
201
CLXVIII
202
CLXIX
204
CLXXI
205
CLXXIII
206
CLXXVI
207
CLXXVII
208
CLXXVIII
209
CLXXX
210
CLXXXI
211
CLXXXIII
212
CLXXXIV
217
CLXXXVII
218
CLXXXVIII
219
CLXXXIX
220
CXC
221
CXCI
222
CXCII
223
CXCIII
224
CXCIV
225
CXCV
226
CXCVI
227
CXCVIII
228
CXCIX
229
CC
230
CCII
237
CCIII
239
CCIV
240
CCV
241
CCVI
242
CCVIII
243
CCX
244
CCXI
246
CCXIII
251
CCXIV
252
CCXV
254
CCXVI
255
CCXVIII
256
CCXIX
257
CCXX
259
CCXXI
260
CCXXIII
261
CCXXIV
263
CCXXVII
269
CCXXVIII
273
CCXXIX
275
CCXXX
276
CCXXXI
277
CCXXXII
278
CCXXXIII
279
CCXXXIV
280
CCXXXV
282
CCXXXVI
283
CCXXXVIII
291
Copyright

Other editions - View all

Common terms and phrases

Popular passages

Page 287 - Folkman, J. (1994). Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315-328.
Page 285 - Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest...

Bibliographic information