Polyamines: Basic and Clinical Aspects : Proceedings of a Satellite Symposium of the 3rd International Congress on Cell Biology, Gifu, Japan, 22-24 August 1984

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Kazutomo Imahori
VSP, Dec 1, 1985 - Science - 528 pages
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The significance of polyamines in cell proliferation and carcinogenesis has stimulated further research interest in their biochemistry and metabolism. These papers, which update the available literature on polyamines, are grouped into four main areas: the metabolism of polyamines; the effect of polyamines on cellular metabolism; inhibitors of polyamine metabolism and their clinical relevance; application to diagnosis and prognosis. The Proceedings include contributions from a wide range of research interests with special emphasis being placed on the clinical aspects of these compounds.
 

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Contents

possible
9
Ornithine decarboxylase activity and cell proliferation
25
general characteristics and
41
Induction of ornithine decarboxylase and spcrmidinespermine Nacetyltransferase
57
Acylpolyamine deacylase from microorganisms and its application to the assaying
73
Partial purification and properties of soybean seedling amine oxidase
89
Distribution of polyumincs in prokaryotes algae plants and fungi
105
Effect of polyamines of cellular metabolism
119
Effect of canavalmine on proliferation and differentiation of murine
293
Steroidlike antiinflammatory effects of arcaine and spermidine analogues
311
A routine application of a simple enzymatic assay to urinary total polyamines
327
A new enzymatic differential assay for diamines spermidine and spermine and their
341
Determination of polyamines in plasma and erythrocytes of digestive cancer
357
Levels of free and acetylated polyamines in human colorectal tumors
375
Cerebrospinal fluid CSF polyamines as markers of meningeal metastasis
383
Clinical evaluation of urinary polyamine levels as cancerassociated markers
399

PolyamineDNA interactions and cancer therapy
135
Isolation of a cDN A clone encoding Sadenosylmethionine decarboxylase from
155
Polyamines and opiates
173
Putrescinemacromolecule complexes detected in vivo by carbon13 nuclear
187
The role of polyamines in restoration of the differentiated phenotype
207
Intercellular pH changes and lysosomal swelling induced by high concentrations
227
Inhibitors of polyamine metabolism and their clinical relevance
243
Potentiation of antitumor activity of adifluoromethylornithine by interferon
251
Novel combined antitumor therapy with polyamine biosynthetic inhibitors
277
Urinary polyamines in patients with urogenital cancer
415
Clinical values of urinary polyamines at various therapeutic stages in hematological
431
Experimental studies on the significance of increased putrescine and cadaverine
447
Studies on the ornithine decarboxylase and polyamines in experimental intrauterine
471
nonspecific component of disease?
487
Synopsis by U Bachrach
501
Concluding remarks by F Suzuki
515
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