Prevention and Treatment of Osteoporosis in the High-Risk Patient: A Clinician's Guide
Cyrus Cooper, Stephen H. Gehlbach, Robert Lindsay
CRC Press, Jan 25, 2005 - Medical - 122 pages
The outcome of recent clinical trials in osteoporosis was the impetus for this volume. In these studies of two bisphosphonates, an interaction between bone mineral density (BMD) and the treatment effect was seen, such that these agents appeared to lose their effect as BMD increased. To practitioners this is counter-intuitive. Why should treatment work and not prevention? This book uses a solid evidence base to explore such issues, without limiting itself to specialist concerns. It tackles other facets of the disease as well, such as the economic aspects. Prevention and Treatment of Osteoporosis in the High-Risk Patient is intended for physicians of all specialties who see patients who have or might be at risk of developing osteoporosis.
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absolute risk alendronate analysis bisphosphonates bone loss Bone Miner Res bone mineral density bone resorption bone turnover breast cancer calcitonin calcium calcium supplementation cardiovascular Clin clinical risk factors collagen controlled trial corticosteroids cost cost-effective decrease Delmas PD disease economic evaluations effect elderly women Engl estimated estrogen etidronate femoral neck fracture in women fracture incidence fracture rates fracture risk fragility fractures hip fracture Hormone replacement therapy identified increase intervention JAMA Johnell Kanis Lancet lifetime risk low BMD markers Melton LJ menopause nonvertebral fractures osteoblast Osteoporos Int 2002 osteoporotic fractures patients placebo controlled population postmenopausal osteoporosis postmenopausal women prevalence of osteoporosis protein raloxifene randomized trials reduce relative risk risedronate risk of fracture risk of hip spine strategies strontium ranelate T-score Tibolone tissue Torgerson DJ treatment of osteoporosis treatment of postmenopausal vertebral deformities vertebral fractures white women women aged women with osteoporosis wrist