Preventive Pharmacotherapy of Headache Disorders
Jes Olesen, Stephen D. Silberstein, Peer Tfelt-Hansen
Oxford University Press, 2004 - Medical - 276 pages
Most of the familiar headache drugs are used to stop a headache attack that is already in progress, or about to begin. However, there is now a growing body of research aimed at developing medications that can be taken on a regular basis to prevent headcahes from starting. These drugs will be targetted at patients whose headaches are frequent or who get their headaches at predicatble times. This book reviews the potential for prophylactic treatment of headache. It provides most of the existing evidence in the field of pharmaco-prophylaxis of migraine and other chronic headaches and may thus, serve as a platform for new initiatives in the field. The book reviews the research into the pharmacological mechanisms involved, the classes of drugs in development and the clinical trials methodology.The editors have gathered together the leading international experts to produce a book that will appeal neurologists caring for headache patients, researchers in the field and those based in the pharmaceutical industry.Readership: Neurologists and general physicians caring for headache patients, and all those with research interest in the field
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19 other sections not shown
5-HT receptor 5-HT1A receptors acid activity acute adverse events agonist amitriptyline analgesic antagonist antidepressants antimigraine arteries attack frequency aura baseline beta-blockers blockade blocker BoNT-A BOTOX Botulinum toxin type brain candesartan cells Cephalalgia cerebral cGMP CGRP chronic tension-type headache clinical trials cluster headache compared crossover decrease depression divalproex sodium dose double-blind duration efficacy enzyme evaluation flunarizine gabapentin Goadsby PJ inhibition inhibitors injection International Headache Society lisinopril lomerizine mechanisms of action medication metoprolol mg daily mg/day migraine attack migraine headache migraine prophylaxis migraineurs mirtazapine month naratriptan Neurology neurones neurotransmitter nitric oxide Olesen pain peptide pharmacological placebo preventive treatment prophylactic drugs prophylactic migraine prophylactic treatment prophylaxis of migraine propranolol randomized RCTs reduction release reported response riboflavin rofecoxib safety sensitization serotonin side effects significant Silberstein SD sumatriptan Table tension-type headache Tfelt-Hansen therapeutic therapy topiramate treatment of migraine trigeminal triptans valproate vascular verapamil weeks