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Principles and Methods for Acute and Subchronic Toxicity
Practical Considerations in the Conduct of Chronic
Methods in Testing for Carcinogenicity
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absorption acid activity agents analysis assay assessment ATPase behavior bioassay Biochem Biol blood body weight brain buffer cage cannula carcinogenic cells centrifuged Chem chemical chronic clearance compound concentration cyclic AMP cytochrome P-450 detection determined dose levels drug effects enzyme evaluation excretion experimental exposure factors fluid function genetic glucose groups guidelines hepatic hepatotoxic homogenate hormone human incubation isolated perfused kidney laboratory animals lipid liver lung male measured membrane ment metabolism metabolites method mice microsomal mitochondria mouse mutagenic mutation nephron normal organ parameters patulin perfused Pharmacol phenobarbital Physiol plasma preparations probit procedure produce protein protocol quantitative rabbit rat liver reaction renal reproductive response rodents sample sensitive serum sodium solution specific studies subchronic substrate Table techniques teratogenic Teratology test article test substance tion tissue tive toxicity Toxicol toxicology transport tube tubular tumor urine vitro vivo xenobiotics