Principles of Experimental Design for the Life Sciences

Front Cover
CRC Press, May 23, 1996 - Science - 176 pages
Let this down-to-earth book be your guide to the statistical integrity of your work. Without relying on the detailed and complex mathematical explanations found in many other statistical texts, Principles of Experimental Design for the Life Sciences teaches how to design, conduct, and interpret top-notch life science studies. Learn about the planning of biomedical studies, the principles of statistical design, sample size estimation, common designs in biological experiments, sequential clinical trials, high dimensional designs and process optimization, and the correspondence between objectives, design, and analysis. Each of these important topics is presented in an understandable and non-technical manner, free of statistical jargon and formulas.
Written by a biostatistical consultant with 25 years of experience, Principles of Experimental Design for the Life Sciences is filled with real-life examples from the author's work that you can quickly and easily apply to your own. These examples illustrate the main concepts of experimental design and cover a broad range of application areas in both clinical and nonclinical research. With this one innovative, helpful book you can improve your understanding of statistics, enhance your confidence in your results, and, at long last, shake off those statistical shackles!
 

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Contents

Introduction and Overview
1
Planning Biomedical Studies
9
Principles of Statistical Design
17
Sample Size Estimation
37
Common Designs in Biological Experimentation
53
Sequential Clinical Trials
83
High Dimensional Designs
103
The Correspondence Between Objectives Design
119
Summary and Concluding Remarks
137
References
143
Appendix B Formulas for Sample Size Estimation
151
Index
157
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