Principles of biochemical toxicology
Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following the acclaimed first two editions of Principles of Biochemical Toxicology, the author has expanded the text to include summary sections, questions and model answers and thoroughly revised artwork. These features, plus the new easy-to-read format, will make biochemical toxicology more accessible to undergraduates and postgraduates encountering the subject for the first time. This comprehensive textbook provides a thorough explanation of dose-response relationships, disposition and metabolism, toxic responses to foreign compounds and detailed examples to illustrate mechanisms of toxicity. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.
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absorption acetylation Amdur New York amines amino acid aniline antibodies antigen aromatic Basis of Pharmacology bile Biochemical Toxicology bromobenzene carbon tetrachloride carcinogenesis carcinogens catalysed cause cells cellular Chapter chromosomes conjugation Consequently covalent binding cytochrome P-450 damage Data diphenylhydantoin distribution dose dose-response Doull drug metabolism edited epoxide ethionine example experimental animals exposure factors foetal foetus foreign compounds gastrointestinal tract genetic glucuronic acid glucuronide glutathione half-life hepatic hepatotoxicity hydrolysis hydroxylation important increased induced inhibition inhibitors interaction involved ionized isoniazid kidney lipid-soluble liver lung M. O. Amdur malformations mechanisms membrane metabolic activation metabolite methyl mg/kg mice microsomal microsomal enzyme molecular molecule mutagens mutation necrosis occur organism oxidase oxidation paracetamol Pharmac phenobarbital plasma concentration plasma level production protein rats reaction reactive intermediate reduced result Science of Poisons soluble species differences structure substrate sulphate synthesis teratogenesis teratogenic tissue toxic toxic compounds toxic effects toxic response transferase tumours vitro vivo