Principles of Drug Action: The Basis of Pharmacology

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William B. Pratt, Palmer Taylor
Churchill Livingstone, 1990 - Medical - 836 pages
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This new edition of Principles of Drug Action is a complete revision of a very-successful graduate-level pharmacology text previously authored by Avram Goldstein, Lewis Aronow and Sumner Kalman. Features: * Thorough survey of the many advances since the previous edition, plus a substantially expanded review of immunopharmacology * Covers basic principles of how drugs affect biological organisms * Explains the principles which govern drug action, absorption, metabolism, and distribution * Provides a solid grounding in modern biochemistry, molecular biology and genetics * Organized around systematic principles rather than drug families or drug effects

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Contents

Molecular Basis of Pharmacologic Selectivity
1
Quantitation of Receptor Occupation and Response
43
Kinetics and Energetics of LigandMacromolecule Complex
68
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