Prions and Mad Cow Disease

Front Cover
Brian K. Nunnally, Ira S. Krull
CRC Press, Oct 17, 2003 - Medical - 413 pages
The alarm sounded by Canada's recently confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent-prion proteins-calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. Administered by an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).
 

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Contents

1 Taking Aim at the Transmissible Spongiform Encephalopathies Infectious Agents
1
2 Prions the Protein Hypothesis and Scientific Revolutions
19
3 A Simulation Model for Evaluating the Potential for Spread of Bovine Spongiform
53
4 Actions to Prevent Bovine Spongiform Encephalopathy from Entering the United States
111
5 Overview of Transmissible Spongiform Encephalopathy in Cervids in the United States
121
6 Bioassays for Prions
132
Implications for Diagnosis
158
Chemiluminescent
174
CEABioRad Test
222
10 The Diagnosis of Transmissible Spongiform Encephalopathies Using Differential
250
11 In Vivo Diagnosis of Prion Diseases
289
12 Diagnosis of Prion Diseases by Multispectral Techniques
304
13 Detection of the Prion Protein in Blood Using a Fluorescence Immunoassay
329
14 Prion Detection and Application to the Safety of Biological Products
347
Index
378
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