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abnormal acute albumin synthesis alcoholic hepatitis alcoholic liver disease amino acids ammonia antibody antigen antipyrine ascites associated bile bilirubin binding biochemical blood flow cholestasis cholesterol chronic active hepatitis chronic alcoholic chronic liver disease cirrhotic patients clearance Clin Invest clinical coma concentration conjugated copper decreased diagnosis dietary dose drug effect elevated enzymes estrogens ethanol excretion factors fatty fibrinogen fluid folate deficiency galactose Gastroenterology halothane hemochromatosis hepatic encephalopathy hepatocellular hepatocytes histologic hormones hyperbilirubinemia increased induced infection interferon intrahepatic iron stores jaundice Kupffer cells LCAT lesion levels liver cell liver function lymphocytes mechanism Medicine metabolism necrosis neomycin normal observed occur oral contraceptives pathogenesis patients with cirrhosis patients with liver patients with PBC platelet portal hypertension pregnancy primary biliary cirrhosis protein reduced renal failure response Reye's syndrome serum shunt sinusoidal steroid studies therapy tion tissue toxic transaminase treatment tumors unconjugated viral hepatitis Wilson's disease