Biotechnology, Products of Secondary Metabolism
H. Kleinkauf, Hans von Döhren
Wiley, Jul 14, 1997 - Science - 743 pages
Products of secondary metabolism from fermentation and cell culture are mainly pharmaceuticals, ranging from traditional antibacterials like beta-lactams, new generation compounds like dalbaheptides and lantibiotics to immunomodulators and antitumor drugs. The major fields of application of these low volume/high price products are human and veterinary medicine as well as plant protection. In this volume functionally based screening approaches and the applications of molecular genetics in the discovery and process improvement of compounds are emphasized. Along with the exploitation of new sources the growing understanding of biosynthetic processes permits the identification of the genetic backgrounds.
Topics included are: Novel Receptor-Active Compounds - Microbial Lipids - Microbial Siderophores - beta-Lactam Antibiotics - Peptide Antibiotics - Lantibiotics - Glycopeptide Antibiotics (Dalbaheptides) - Aminoglycosides - Products from Basidiomycetes - Cyclosporins - Secondary Products from Plant Cells - Antitumor Agents
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HANS VON DOHREN
Secondary Metabolism an Expression of Cellular and Organismic Individuality
Variability of Structures of Secondary Metabolites
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A-factor actinomycetes actinorhodin Afsk alkaloids amino acid aminoglycosides ANKE anthracyclines anti antibacterial antibiotic production antifungal antitumor Aspergillus B-lactam Bacillus Bacillus subtilis bacteria Bacteriol BEPPU binding Biochem Biochemistry Biol biosyn biosynthesis biosynthetic genes Biotechnol biotic cell cultures characterization Chem chemical chrysogenum Cloning coli complex compounds cyclophilin cyclosporin cytotoxic derivatives DOHREN domain drugs duction encoding enzyme factors fatty acids fermentation formation fungi gene gene cluster genetic glycopeptide griseus growth HORINOUCHI inhib inhibition inhibitors involved isolated KLEINKAUF lipid membrane metabolism microbial Microbiol microorganisms moiety molecular molecule mutants mycin nisin novel OH OH pathway penicillin peptide phosphorylation PIEPERSBERG Plant Cell polyketide ppGpp precursor RATLEDGE receptor regulation regulatory residues role SAHL secondary metabolites Sect sequence siderophore specific strains Strepto Streptomyces coelicolor Streptomyces sp structure substrate subtilin subtilis synthase synthesis synthetase taxol teicoplanin tion transcription tures vancomycin yeast