Programming HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

Front Cover
Rachel Yehuda, Nikolaos P Daskalakis
Frontiers Media SA, Mar 16, 2015 - Diseases of the endocrine glands. Clinical endocrinology - 140 pages

Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.




 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

implications for resilience and susceptibility to physical and mental disorders
5
systematic review of contributing factors
8
early trauma and depression
16
Earlylife stress HPA axis adaptation and mechanisms contributing to later health outcomes
28
Neurocircuitry underlying stress and emotional regulation in animals prenatally exposed to alcohol and subjected to chronic mild stress in adulthood
45
Glucocorticoid programing of the mesopontine cholinergic system
59
Context modulates outcome of perinatal glucocorticoid action in the brain
70
Immediate effects of maternal deprivation on the reactivity of the HPAaxis differ in CD1 and C57Bl6J mouse pups
83
Age and sexdependent effects of early life stress on hippocampal neurogenesis
89
Social isolation disrupts hippocampal neurogenesis in young nonhuman primates
100
rodents and humans
109
immediate and enduring effects on neurobehavioral and stress axis development
114
Effects of an early experience involving training in a Tmaze under either denial or receipt of expected reward through maternal contact
129
Maternal age at Holocaust exposure and maternal PTSD independently influence urinary cortisol levels in adult offspring
133
Copyright

Common terms and phrases

Bibliographic information