Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs
SCI, Jan 1, 1999 - Medical - 217 pages
Knowledge of the invertebrate nervous system and target sites for both pesticides and drugs within it has advanced greatly during the last decade. It is hoped that increased communication between invertebrate neurobiology scientists and those working on its practical applications in pest control, for example, will lead to a more rational approach to the design of pesticides and a better understanding of resistance. This unique book presents the latest research in this area, as well as discussing the nervous system as a potential target for drugs. Encompassing ion channels and receptors, molecular neuroscience, natural products and neurotoxicity, Progress in Neuropharmacology and Neurotoxicology of Pesticides and Drugs brings together pesticide scientists from industry with academic neuroscientists. Leading international experts in the field contribute their findings on serotonin, acetylcholine and GABA receptors, and sodium and calcium channels, as well as innovative items on animal toxins and the neurotoxicity of pesticides. This book is essential reading for anyone wishing to discover the most recent developments in this field, whether as biochemist, neuroscientist, toxicologist or pesticide researcher.
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Ion Channels and Receptors as Targets
Ion Channels and Receptors
Neurotoxic Insecticides as Target Site Radioligands and Photoaffinity Probes
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acetylcholine action activity agonists amino acid assays barbiturates binding Biol body wall muscle calcium channel cDNA cells Chem chemical chloride channel cholinergic cismethrin cloned compounds concentrations cyclic AMP cypermethrin deltamethrin depolarization dieldrin DmcalD dopamine dose Drosophila effect elegans encoding excitatory Figure functional G-protein GABA GABAA receptors gene genetic genome heptachlor house fly imidacloprid inactivation increase inhibition insect Insect Biochem insect sodium channels insecticides interaction intracellular ion channels ivermectin J.E. Casida levamisole mammalian membrane modified modulation molecular MPTP muscarinic mutation Narahashi nematode neurons Neurosci nicotinic ACh receptors nicotinic receptor octopamine oocytes oocytes expressing pentobarbitone peptide pest Pestic Pesticide Pharmacol pharmacological phenobarbitone photoaffinity Physiol picrotoxin potential protein pyrethroids radioligand reduced resistance responses scorpion second messenger sensitive sequence sodium channels sodium current specific structure studies subunit super-kdr synaptic target tetramethrin TipE toxicity toxin tyramine vertebrate voltage dependence Vsscl Vsscl/tipE sodium channels Xenopus oocytes Zlotkin