Protein Kinase a and Human Disease, Volume 968
Constantine A. Stratakis, Yoon S. Cho-Chung
New York Academy of Sciences, 2002 - Medical - 271 pages
Protein kinase A (PKA) is an enzyme that modulates the function of other proteins and thus is involved in many processes responsible for cellular regulation. This volume follows the discovery of the first human genetic disorder that is caused by mutations of one of the sub-units of the PKA system. It brings together clinical and basic scientists for an examination of the enzyme and its involvement in human disease.
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Acad ACTH adenomas adenylyl cyclase adrenal adrenocortical adrenocortical carcinoma AIMAH allele antisense apoptosis binding Biochem Biol breast cancer cAMP-dependent protein kinase cancer cells carcinoma Carney complex catalytic subunit cell cycle cell growth cell lines cell proliferation cellular Chem CHO-CHUNG chromosomal Clin CREB Cushing's syndrome cyclic AMP defects differentiation disease effects endocrine Endocrinol exon expression function G protein gene Genet growth factor hedgehog holoenzyme hormone human hyperplasia imprinting induces inhibition inhibitors insulin interaction intracellular isoforms isozyme macronodular malignant MAPK maternal McCune-Albright syndrome mechanism mediated membrane Metab mice mitogenic molecular mouse mRNA mutations Natl normal Oncogene overexpression patients phenotype phosphorylation PHPIA PKA activity PKA-I PLD2 PRKAR1A Proc pseudohypoparathyroidism PTEN receptor regulation regulatory subunit RIIB RIO subunit role signaling pathways Sonic hedgehog specific stimulation studies synthesis target thyroid thyroid cells tion tissues transcription factors transformation tumors vitro vivo