Proto-Oncogenes in Cell Development
The role of certain genes in the uncontrolled cellular growth that constitutes cancer has been studied intensively for several years. These oncogenes are often viral genes that have been integrated into the genome of the cell. It is now known that the viral genes are mutated versions of normal cellular genes involved in the control of growth and development. The mutant genes fail to respond to regulatory signals in the cell, resulting in unrestrained proliferation.
What people are saying - Write a review
We haven't found any reviews in the usual places.
This symposium is based on a proposal made by Dr Michael Hanley
R Hanley W T Cheung P Hawkins D Poyner H P Benton
J Meinkoth A S Alberts and J R Feramisco Construction of mammalian
16 other sections not shown
Other editions - View all
Acad Sci USA adenovirus amino acids angiotensin antibodies assay astrocytes binding bradykinin Brugge c-myc Cancer cdc2 cDNA cell cycle cell lines cellular cloned complex cyclin cytoplasmic differentiation dimerization DNA synthesis domain Drosophila embryo encodes expression Feramisco fibroblasts function gene product growth cone Hafen Hanley Harlow homologue human Hunter immunoprecipitated induced interaction kinase activity levels ligand mammalian Maness mitogenic mitosis Mol Cell Biol monoclonal antibody mouse mRNA mutant myoblasts Natl Acad Sci Nature Lond neuronal Norbury normal oligodendrocytes oncogene oocytes optic nerve pathway PDGF receptor peptide phenotype phospholipase phosphorylation platelet-derived growth factor PLC7 pp60c src Proc Natl Acad progenitor cells protein kinase proto-oncogene Raff region regulation role Science Wash DC sequence serum sevenless Sherr signal transduction specific stimulation substrate subunit transcription transfected transformation tubulin tumours type-1 astrocytes tyrosine kinase tyrosine phosphorylation Vande Woude Verma viral vitro Westermark wild-type Xenopus yeast