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On the choice of a sequential test procedure
An efficient design for comparing the effects of two treatments
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action agonist analgesics analysis animals antibiotic applied Ariens asymptotic reactor bio-assay Biometrics calculated CCNSC chlorpromazine clinical combined compared comparison competitive antagonist compounds computed concentration confidence interval considered cystamine decision dose level dose response dose response line dose-response curves drop drug effect Emmens equal equation estimate example experimental experiments Finney fortified Test function given hypothesis injected interaction intrinsic activity irradiation isobole Laboratory log dose material mathematical maximum likelihood means Neth non-parametric methods normal distribution observations obtained paper parallelism parameter patients penicillin pharmacological possible prednisone preparation probit problem procedure quantal quantal response rank rankits ratio rats reactor rule receptors regression lines rejection relative potency Research sample test screening sequential test significance slope spasmolytic standard statistical Student's test substance Table temperature therapeutic index tion toxicity transform treatment trial triplet tumor type I error validity values variance variation Wilcoxon's test