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4CMB Acad alkylating agents Ames and McCann analysis animal carcinogens Ashby B.N. Ames bacterial mutagenicity bacterial mutation Bartsch bioassays biologic calculated Cancer Inst Cancer Res carcino carcinogenic potency carcinogenicity and mutagenicity carcinogenicity data chemical carcinogens Chemical Environmental Mutagens chemical mutagens compounds conclusion DNA damage DNA repair dose-response curve doses Drosophila e_t a_l end points estimates experimental extrapolation factor genetic genicity genotoxicity human cancer human carcinogenicity Human Risk Assessment IARC interspecies Knudson Lijinsky lymphoma Malaveille malignant mammalian cells Meselson and Russell metabolism microsome microsome test muta mutagenesis mutagenic activity mutagenic and carcinogenic mutagenic potency mutagenicity assays National Research Council Natl nitrosamines noncarcinogens oncogene Peto potential predict Proc procarcinogens qualitative quantitative correlation relationship between mutagenicity retinoblastoma rodent Salmonella Salmonella/microsome test short-term mutagenicity tests short-term tests somatic mutation species Squire suggested susceptible test systems Toxicology transformation tumor ultimate carcinogens V79 Chinese hamster vitro Wilms Xeroderma pigmentosum XP patients