Rabies: Scientific Basis of the Disease and Its Management
Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.
* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases’ unique horror
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Chapter 12 Immunology
Chapter 13 Human Rabies Vaccines
Chapter 14 Animal Vaccines
Chapter 15 Next Generation Rabies Vaccines
Chapter 16 Public Health Management of Humans at Risk
Chapter 17 Dog Rabies and its Control
Chapter 18 Rabies Control in Wild Carnivores
Chapter 19 Future Developments and Challenges
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Africa America animals antibody antigen apoptosis assay Australian bat lyssavirus Baer baits bat lyssavirus bat rabies Big brown bat bite Bourhy brain canine rabies cats cell culture rabies Centers for Disease clinical culture rabies vaccines detection developed diagnosis Dietzschold Disease Control dog rabies epidemiology European bat lyssavirus experimental exposure fox rabies gene genetic genome genotype glycoprotein host human rabies immune response Infectious Diseases inoculation Jackson Journal of Virology Journal of Wildlife Koprowski Kuzmin laboratory Medicine methods mice Microbiology Mokola virus MOKV molecular monoclonal antibodies Nadin-Davis Negri bodies neurons pathogenesis pathogenic patients population post-exposure primers protein rabid rabies control rabies virus rabies virus infection rabies virus variants RABV raccoon rabies receptor recombinant red fox reported reservoir Rosatte Rupprecht saliva samples sequence serum skunks Smith species studies surveillance tion tissue titers Tordo transmission vampire bat viral virions viruses Wandeler Wildlife Diseases World Health Organization Wunner
Page 21 - Smith, JS (1989). Rabies virus epitopic variation: Use in ecologic studies. Advances in Virus Research 36, 215-253. Smith, JS, Orciari, LA, Yager, PA, Seidel, HD and Warner, CK (1992). Epidemiologic and historical relationships among 87 rabies virus isolates as determined by limited sequence analysis.