Rabies: Scientific Basis of the Disease and Its Management

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Academic Press, Jul 26, 2010 - Science - 680 pages
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Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes.

* Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow fever, dengue fever, or Japanese encephalitis
* More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year
* New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled
* Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed
* Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation
* Includes an increase in illustrations to more accurately represent this diseases’ unique horror
 

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Contents

Chapter 1 The History of Rabies
1
Chapter 2 Rabies Virus
23
Chapter 3 Molecular Epidemiology
69
Chapter 4 Epidemiology
123
Chapter 5 Rabies in Terrestrial Animals
201
Chapter 6 Bat Rabies
259
Chapter 7 Human Disease
309
Chapter 8 Pathogenesis
341
Chapter 12 Immunology
489
Chapter 13 Human Rabies Vaccines
505
Chapter 14 Animal Vaccines
517
Chapter 15 Next Generation Rabies Vaccines
531
Chapter 16 Public Health Management of Humans at Risk
545
Chapter 17 Dog Rabies and its Control
573
Chapter 18 Rabies Control in Wild Carnivores
595
Chapter 19 Future Developments and Challenges
635

Chapter 9 Pathology
383
Chapter 10 Diagnostic Evaluation
411
Chapter 11 Rabies Serology
471

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Popular passages

Page 21 - Smith, JS (1989). Rabies virus epitopic variation: Use in ecologic studies. Advances in Virus Research 36, 215-253. Smith, JS, Orciari, LA, Yager, PA, Seidel, HD and Warner, CK (1992). Epidemiologic and historical relationships among 87 rabies virus isolates as determined by limited sequence analysis.
Page 634 - H., 1984, Protection from rabies by a vaccinia virus recombinant containing the rabies virus glycoprotein gene, Proc.

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About the author (2010)

Dr. Jackson is Professor of Medicine (Neurology) and of Medical Microbiology and also Head of the Section of Neurology at University of Manitoba in Winnipeg, Manitoba, Canada. He graduated from Queen’s University with BA and MD degrees. He completed an internship in internal medicine at University of Southern California, residencies in internal medicine at Queen’s University and in neurology at the University of Western Ontario, and a fellowship in neurovirology at The Johns Hopkins University with Drs. Richard Johnson and Diane Griffin. Dr. Jackson held a faculty position at Queen’s University from 1987 - 2007. He is on the Editorial Boards of the Journal of NeuroVirology and the Canadian Journal of Neurological Sciences. He is President of Rabies in the Americas, Inc. and is on the Board of Directors of the International Society for Neurovirology. Dr. Jackson is the principal investigator on research grants to study experimental aspects of rabies.

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