Receptors For Extracellular Matrix
Academic Press, Dec 2, 2012 - Science - 344 pages
Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions.
Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family.
This book is of great value to cell biologists and researchers.
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Chapter 3 Multidomain Proteins of the Extracellular Matrix and Cellular Growth
Chapter 4 Neural Cell Adhesion Molecule and Polysialic Acid
Chapter 5 Regulation of Neural Development by the Extracellular Matrix
Other editions - View all
Acad activity adhesion receptors afﬁnity amino acid anchorin CII antigen axons basal lamina basement membrane Bernﬁeld binding Biochem C3bi cDNA cell adhesion molecule cell attachment Cell Biol cell migration cell surface proteoglycan cell-binding cell—cell cellular chain Chem cloning collagen cultured cytoskeleton deﬁciency differentiation ECM components ECM proteins EGF receptor EMBO embryonic endothelial cells epithelial cells expression extracellular matrix ﬁbrinogen ﬁbronectin ﬁbronectin receptor ﬁrst fragments function gene glycoprotein Hemler heparan sulfate heparin heterodimers homology human Hynes identiﬁed Immunol inhibit integrin integrin receptors interactions involved keratinocytes kinase laminin LeuCAMs leukocyte LFA-l ligand lymphocyte mediate mitogenic molecular monoclonal antibodies monocytes mouse Natl NCAM neural cell adhesion neural crest cells neurite neurons neutrophil peptides phosphorylation platelet Proc proliferation region regulation role Ruoslahti Rutishauser sequence speciﬁc splicing Springer stimulated structure studies substrate subunit syndecan tenascin thrombospondin Timpl tion tissue transmembrane tyrosine vitro vivo Yamada