Regenerative Therapy Using Blood-Derived Stem Cells

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David S. Allan, Dirk Strunk
Springer Science & Business Media, Nov 16, 2011 - Science - 220 pages
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Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine.

 

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Contents

Undertaking Regenerative Medicine Studies with Blood Stem Cells
1
Defining Endothelial Progenitor Cells
9
BloodDerived ALDH hi Cells in Tissue Repair
20
Mesenchymal Stem Cells and Tissue Repair
35
Animal ProteinFree Expansion of Human Mesenchymal StemProgenitor Cells
53
Defining Hierarchies of Unrestricted Somatic Stem Cells and Mesenchymal Stem Cells in Cord Blood
70
Induced Pluripotent Stem Cells from Blood
87
Endothelial Progenitors and Repair of Cardiovascular Disease
96
Regenerative Potential of Blood Stem Cell Products Used in Hematopoietic Stem Cell Transplantation
124
Concepts to Facilitate Umbilical Cord Blood Transplantation
141
Cord Blood Banking for Regenerative Therapy
157
Regulatory Questions in the Development of Blood Stem Cell Products for Regenerative Therapy
166
Cell Therapy Regulations from a European Perspective
190
EBMT Registry of Nonhematopoietic Stem Cells and Regenerative Therapy Cellular and Engineered Tissue Therapies in Europe
205
Index
210
About the Editors
216

Bone MarrowDerived Cells as Treatment Vehicles in the Central Nervous System
109

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About the author (2011)

Dr. David S. Allan is a clinician scientist at the Ottawa Hospital Research Institute, affiliated with the Blood & Marrow Transplant Program at the University of Ottawa. His research interests focus of fundamental aspects of vascular progenitor biology and on translational studies in the repair of organ toxicity in patients undergoing hematopoietic stem cell transplantation.

Dr. Dirk Strunk is a clinician scientist with the Hematopoietic Stem Cell Transplantation Program and Head of Stem Cell Research at the Medical University of Graz in Austria. His research team develops novel transplantation strategies using mesenchymal stromal cells and endothelial progenitors and has developed animal protein-free methods of cell expansion that facilitate translational studies in humans.

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