Regenerative Therapy Using Blood-Derived Stem CellsDavid S. Allan, Dirk Strunk Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine. |
Contents
1 | |
9 | |
20 | |
Mesenchymal Stem Cells and Tissue Repair | 35 |
Animal ProteinFree Expansion of Human Mesenchymal StemProgenitor Cells | 53 |
Defining Hierarchies of Unrestricted Somatic Stem Cells and Mesenchymal Stem Cells in Cord Blood | 70 |
Induced Pluripotent Stem Cells from Blood | 87 |
Endothelial Progenitors and Repair of Cardiovascular Disease | 96 |
Regenerative Potential of Blood Stem Cell Products Used in Hematopoietic Stem Cell Transplantation | 124 |
Concepts to Facilitate Umbilical Cord Blood Transplantation | 141 |
Cord Blood Banking for Regenerative Therapy | 157 |
Regulatory Questions in the Development of Blood Stem Cell Products for Regenerative Therapy | 166 |
Cell Therapy Regulations from a European Perspective | 190 |
EBMT Registry of Nonhematopoietic Stem Cells and Regenerative Therapy Cellular and
Engineered Tissue Therapies in Europe | 205 |
Index | 210 |
About the Editors | 216 |
Other editions - View all
Regenerative Therapy Using Blood-Derived Stem Cells David S. Allan,Dirk Strunk No preview available - 2014 |
Regenerative Therapy Using Blood-Derived Stem Cells David S. Allan,Dirk Strunk No preview available - 2011 |