Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves

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Basic Books, 2012 - Nature - 284 pages
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Everyone has heard of genetic engineering: we eat engineered foods, we take drugs made in engineered bacteria and yeast, and someday soon may drive our cars on fuel produced by engineered microorganisms. "Regenesis" is the story of where these technologies came from, and where theyOCOre going, told by the man leading the revolution: Harvard genetics professor George Church.
While traditional genetic engineering introduces changes to an organism a few genes at a time, genomic engineering introduces changes on a wholesale basis, allowing for unprecedented feats of synthetic biological engineering. (The technique, called MAGE, was invented by the author.) In "Regenesis," Church argues for the great potential of this technology, not only to make existing organisms more useful, but for inventing wholly new speciesOCobacterial, animal, and human. It promises to be a strange future, with biohackers building organisms in their garages, companies manufacturing toolkits of DNA parts for creating living machines, and much else.
Researchers have already managed to get microbes to produce jet fuel, gasoline, and electricity. And even vaccines, drugs, and industrial chemicals (OC green chemistryOCO). They can reprogram bacteria to metabolize greenhouse gases and convert them into harmless, even beneficial substances. Still, incredible as they might seem, these exploits are minor advances compared to the catalog of wonders that full-blown genomic engineering will make possible, from resurrecting woolly mammoths and other extinct organisms to creating mirror life forms immune to disease.
The rise of synthetic biology marks a fundamental transformation in the relationship between biology and nature. When humans can control the genetic makeup of organisms to the extent foreseen by synthetic biologists, nature will no longer be the exclusive arbiter of life, death, and evolution. "Regenesis" reveals what this not so far off future will look like.

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User Review  - greeniezona - LibraryThing

Just when I was starting to feel a little self-conscious about my list so far being dominated by graphic novels and children's books, I managed to plow through this tome. Okay, that's an unfair ... Read full review

REGENESIS: How Synthetic Biology Will Reinvent Nature and Ourselves

User Review  - Jane Doe - Kirkus

A heady overview of the emerging discipline of synthetic biology and the wonders it can produce, from new drugs and vaccines to biofuels and resurrected wooly mammoths.In this authoritative, sometimes ... Read full review

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About the author (2012)

George Church is Professor of Genetics at the Harvard Medical School and member of the Wyss Institute of Biologically Inspired Engineering. He is the director of the Lipper Center for Computational Genetics, the Harvard DOE Genomes-to-Life Center, the NIH Center for Excellence in Genomic Science, and Church was the driving force behind the Polonator G.007, a low-cost automated genomic sequencing machine. He lives in Brookline, Massachusetts.
Ed Regis is author of seven science books, most recently "What Is Life?: Investigating the Nature of Life in the Age of Synthetic Biology." He lives in Sabillasville, Maryland.

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