Registry of Toxic Effects of Chemical Substances, Rtecs: A Comprehensive Guide

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DIANE Publishing, 1993 - Medical - 70 pages
Describes the types of data, and their format, in the 1993 edition of RTECS. Includes detailed file description: computer tape, on-line and CD-ROM. The database has expanded to include primary skin and eye irritation, mutagenic effects, reproductive effects, tumorigenic effects, and acute toxicity data. A most important recent addition is other toxic effects data from multiple dose studies.
 

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this is not exactly into toxicity effects

Contents

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Page 30 - Hazardous material means a substance or material, which has been determined by the Secretary of Transportation to be capable of posing an unreasonable risk to health, safety, and property when transported in commerce, and which has been so designated.
Page 24 - Dose units are usually given as an amount administered per unit body weight or as parts of vapor or gas per million parts of air by volume.
Page 26 - ... narcosis of sufficient degree to increase accident proneness, impair self-rescue, or materially reduce work efficiency, provided that NO MORE THAN FOUR EXCURSIONS PER DAY ARE PERMITTED, with at least 60 MINUTES BETWEEN EXPOSURE PERIODS, and provided that the daily TLV-TWA also is not exceeded.
Page 28 - Evidence is available when, because of major qualitative or quantitative limitations, the studies cannot be interpreted as showing either the presence or absence of a carcinogenic effect.
Page 23 - Fifty--a calculated dose of a substance which is expected to cause the death of 50% of an entire defined experimental animal population. It is determined from the exposure to the substance by any route other than inhalation of a significant number from that population.
Page 23 - A calculated concentration of a chemical in air to which exposure for a specific length of time is expected to cause death in 50% of a defined experimental animal population. Lethal...
Page 26 - Hygienists (ACGIH) maximum concentration to which workers can be exposed for up to 15 min continually. No more than four excursions are allowed per day, and there must be at least 60 min between exposure periods. The daily Threshold Limit Value - Time Weighted Average (TLV-TWA) may not be exceeded.
Page 37 - Activity is demonstrated by studies that are interpreted as showing a chemically related increased incidence of neoplasms (malignant, benign, or combined) in which the strength of the response is less than that required for clear evidence.
Page 23 - LDSO) of a material introduced by any route, other than inhalation, over any given period of time in one or more divided portions and reported to have caused death in humans or animals.
Page 27 - SUFFICIENT EVIDENCE of carcinogenicity is provided when there is an increased incidence of malignant tumors: (a) in multiple species or strains; or (b) in multiple experiments (preferably with different routes of administration or using different dose levels); or (c) to an unusual degree with regard to the incidence, site or type of tumor, or age at onset.

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