Relationships between chemical structure and rat repellency: II. compounds screened between 1950 and 1960
Food Engineering Laboratory, US Army Natick Laboratories, 1974 - Medical - 378 pages
Over 4,600 compounds, chiefly organic types, were evaluated using both a food acceptance test and a barrier penetration bioassay to correlate relationships between chemical structure and rodent repellency. These chemicals are indexed and classified according to the functional groups present and to the degree of substitution within their molecular structures. The results of reduction in food consumption for each compound appraised are calculated and their K values listed. The repellent activities of the functional groups represented, alone or in combinations, are expressed by a Functional Group Repellency Index. There were 123 active, interesting or promising compounds included in the 699 having K values of 85 or greater, which were selected for the barrier appraisal study. These chemicals were formulated in selective solvents at several concentrations and applied to burlap, and exposed to rodent attack following storage periods of varying intervals. The results of these tests are listed.
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