Report of Commission of Medical Officers Detailed by the Authority of the President to Investigate the Cause of Yellow Fever

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U.S. Government Printing Office, 1899 - 98 pages
 

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Page 9 - Sternberg and this highly infectious disease, and that the bacillus x is frequently found in the intestinal content of normal animals and of man, as well as in the urine and the bronchial secretion. "(/) That, so far as your commission is aware, the bacillus icteroides has never been found in any body other than one infected with yellow fever, and that whatever may be the cultural similarities between this and other micro-organisms, it is characterized by a specificity which is distinctive. "(8...
Page 10 - That the bacillus icteroides produces in vitro, as well as in vita, a toxin of the most marked potency, and that, from our present knowledge, there exists a reasonable possibility of the ultimate production of an antiserum more potent than that of Professor Sanarelli.
Page 11 - And to these may be added a fifth requirement, viz: 5. That the chemical products of the organism when introduced into the tissues must produce symptoms and effects (but not necessarily the lesions) of the disease. Have all of these requirements been fulfilled in the case of every acute, specific, infectious, or contagious disease ? The answer must be, in all fairness, no.
Page 9 - Sanarelli, of the University of Bologna, Italy, and by him named " bacillus icteroides," is the cause of yellow fever. 2. That yellow fever is naturally infectious to certain animals, the degree varying with the species ; that in some...
Page 9 - bacillus icteroides," is the cause of yellow fever. 2. That yellow fever is naturally infectious to certain animals, the degree varying with the species; that in some rodents local infection is very quickly followed by blood infection, and that, while in dogs and rabbits there is no evidence of this subsequent Invasion of the blood, monkeys react to the infection the same as man. 3. That infection takes place by way of the respiratory tract, the primary colonization in this tract giving rise to the...
Page 9 - That there exists no causal relationship between the Bacillus X of Sternberg and this highly infectious disease, and that the Bacillus X...
Page 8 - The findings of this Commission, verifying the discovery made by Sanarelli, and making still further advances than did Sanarelli himself by determining the specificity of the bacillus icteroides, and that the primary infection of yellow fever is received through the respiratory tract, in other words, verifying one discovery and making others of almost equal importance, at the same time eliminating incorrect theories, must be considered a notable achievement in medical science and one of...
Page 62 - ... when climatic conditions are favorable for its growth. It may be that such a nidus is essential, and that the culture media usually employed by bacteriologists do not afford a suitable soil for this particular microbe. It is also possible that its development depends upon the presence of other...
Page 80 - ... last hours of life." From this we could almost assume that the organisms in question can originate de novo, and if it can give rise to yellow fever, then the old theory of the spontaneous evolution of this disease is again introduced. We can not assent to this proposition. The work of Sternberg, who says, "In the series of cases studied by me secondary infections were extremely rare,"1 and the work of Sanarelli and our own is opposed to the barest possibility that the bac.
Page 9 - ... or a secondary colonization of this organism in the blood of the patient. This secondary infection may be complicated by the coinstantaneous passage of other organisms into the blood, or this complication may arise during the last hours of life.

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