Reproductive Toxicology: In vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand
Jesús del Mazo
Springer, Oct 31, 1998 - Medical - 223 pages
Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.
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activity alive fetuses alkaline analysis androgen animals antibody apoptosis assessment benomyl binding Biochem Biol breast cancer cell lines cell proliferation cellular chemicals chromosome CIS cells clones comet assay comet tail compounds concentrations culture Cuzin decrease detection developmental differentiation DNA damage DnaJ dopamine agonist dose E-SCREEN assay embryos endometrial endosulfan environmental estradiol estrogen receptor exposure expression Felici female fertility fetal Figure function gene growth factors hormone human sperm human spermatozoa implantation increase induced inhibition interaction irradiated lactate levels Leydig cell male germ mammalian marker MCF7 cells meiotic method mg/kg minisatellite mutation normal oocytes organochlorine pachytene parathion PGCs placenta primordial germ cells production progesterone protein radiation Reproductive Toxicology samples seminiferous Sertoli cells serum Skakkebaek somatic cells Sonnenschein Soto species sperm motility spermatids spermatocytes spermatogenesis spermatozoa steroid steroidogenesis testicular testis testosterone tissue transgenic transgenic mice treatment vitellogenin vitro vivo xenobiotics xenoestrogens yolk sac