Research plan for endocrine disruptors
Gerald T. Ankley, United States. Environmental Protection Agency. Office of Research and Development
Office of Research and Development, U.S. Environmental Protection Agency, 1998 - Medical - 47 pages
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adverse effects areas assays bioaccumulate biological effects biomarkers cancer CENR concentrations of EDCs coordination developmental dose-response Ecological Focus ecological risk ecosystem EDC exposure effects and exposure effects of EDCs effort endocrine disrupting chemicals endocrine disruptors endocrine system endometriosis environment EPA's estrogenic evaluate exposed exposure and effects Exposure Assessment Exposure Focus exposure research exposure to EDCs extramural extrapolation health and ecological health effects High Priority Adjusted hormone human and ecological human and wildlife Human Focus human health identify intramural issues levels LINKAGE lssue Medium Priority Adjusted multiple EDCs organisms phytoestrogens potential predict Priority Adjusted Score priority score processes prostate cancer QSAR Quantitative Structure-Activity Relationships receptor relevant reproductive research needs research plan research program research strategy risk management risks of EDCs Score from Appendix screening sex steroids STUDlES suspect EDCs testing toxicity toxicology uncertainties unreasonable risks vitellogenin wildlife populations wildlife species workshops
Page 1 - EDCs have been defined as exogenous agents that interfere with the production, release, transport, metabolism, binding, action, or elimination of the natural hormones in the body responsible for the maintenance of homeostasis and the regulation of developmental processes.
Page 10 - (1) a comprehensive mission statement covering the major functions and operations of the agency; "(2) general goals and objectives, including outcome-related goals and objectives, for the major functions and operations of the agency; "(3) a description of how the goals and objectives are to be achieved, including a description of the operational processes, skills and technology, and the human, capital, information, and other resources required to meet those goals and objectives...
Page 8 - In general, due to the precise yet adaptable control mechanisms and the intertwined nature of hormonal balance, modest amounts of chemical exposure seldom compromise normal physiological functions. Fluctuations of hormone concentration and receptor activities, by design, absorb some of environmental and physiological challenges to maintain homeostasis in adults. Only when the equilibrium control mechanisms are overwhelmed do deleterious effects occur. An important question is whether homeostatic...
Page ii - It has been subjected to the Agency's peer and administrative review and has been approved for publication as an EPA document. Mention of trade names or commercial products does not constitute endorsement or recommendation for use.
Page 34 - ... and are similar in structure and action to endogenous estrogen. Although the public health significance and descriptive terminology of substances capable of affecting the endocrine system remains controversial, scientists agree that these chemicals may affect the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body responsible for maintaining homeostasis, reproduction, development, and/or behavior (EPA 1997).
Page 2 - CENR workgroup are to: develop a federal research framework; inventory ongoing research activities in the federal government and elsewhere; provide a forum for information sharing among the various national organizations; outreach to non-federal organizations involved in endocrine disrupter issues; and hold periodic symposia as the research emerges. The inventory of federal research on endocrine disruption has been used to evaluate the current state of the federal effort, identify research gaps and...
Page 5 - ... and existing chemicals for their ability to cause potential adverse human health and environmental effects and requiring the gathering of data on environmental exposure levels and potential human health and ecological effects when data are insufficient; and 8) reviewing and analyzing information that pesticide manufacturers submit in support of registration or reregistration to determine that a pesticide will not cause unreasonable adverse effects on the environment or to humans.
Page 1 - In addition, reports of declines in the quality and quantity of sperm production in humans over the last four decades, and increases in certain cancers that may have an endocrine-related basis (breast, prostate, testicular) have led to speculation about environmental etiologies. Despite these reported effects, we know little about their causes and the concentrations of EDCs that would induce effects in various populations. Nevertheless, it is known...
Page 2 - ... federal effort, identify research gaps and establish priorities, and clarify governmental roles and responsibilities. To date, nearly 400 projects have been identified as being sponsored by the participating 14 agencies. The CENR framework and the inventory are available on the Internet (http://www.epa.gov/endocrine), and a summary analysis has been published (Reiter, et al, 1998). Due to the complex nature of the uncertainties posed by the endocrine disruptor hypothesis, the overlapping concerns...
Page 11 - Disrupters goals and objectives. Each agency is also required to submit a performance plan covering each program activity set forth in the Agency's budget, which must be consistent with the strategic plan. ORD's research on endocrine disrupters falls under EPA's "Goal 8: Sound Science, Improved Understanding of Environmental Risk, and Greater Innovation to Address Environmental Problems. Objective 3: Emerging Risk Issues. Subobjective 3.2: Endocrine Disrupters.