Retinoids: Progress in Research and Clinical Applications

Front Cover
Maria A Livrea, Lester Packer
CRC Press, Jan 18, 1993 - Science - 672 pages
This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications, held in 1991 in Palermo, Italy, describing the latest research findings on biochemistry, nutrition, molecular and cell biology and developmental biology, as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by leading authorities in the field from the USA, Europe and Japan, Retinoids, amongst other things: addresses retinol-supported retinoic acid (RA) synthesis and catabolism; identifies synthetic ligands with a high selective affinity for RAR-alpha, -beta and -gamma nuclear receptors, determining if they would show pharmacological properties similar to the natural parent substance all-trans RA; considers the embryonic/foetal cellular retinoid-binding proteins and evidence for their participation in normal and abnormal morphogenesis; discusses a novel arotinoid, Ro 40-8757, that exhibited improved anti-tumour efficacy and safety in pre-clinical tests; and reports the audioradiographic distribution of retinol and RA in organs of pregnant hamsters and foetuses.
 

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Contents

Metabolism and Nutrition
1
Interactions of Retinoids with Lipid Bilayers and with
17
Retinoids Are Actively Metabolized in Rabbit Bone Marrow
63
RetinolBinding Protein Expression and Its Regulation
73
Plasma RetinolBinding Protein and Its Interaction with
91
Role of Fatty AcidBinding Protein as a Vehicle
103
Roles of Cellular RetinolBinding Protein and Cellular
119
Vitamin ABinding Proteins in the Cells of
121
Modulation of Cell Proliferation and Differentiation
311
Biochemical Regulation of Transglutaminase Activity
341
Mechanistic Studies of Cancer Chemoprevention
361
Teratogenicity
383
Transforming Growth Factor 8s in Early Mouse
397
Cellular Retinoic AcidBinding Proteins in the Pathogenesis
411
An Autocatalytic Morphogen
439
Breast Cancer Chemoprevention with Retinoids
453

RetinolBinding Protein Expression and Its Regulation
129
Enzymatic Synthesis of Retinoic Acid in Retina
147
RetinolBinding Proteins and the Alltrans to 11cis
159
The Epidemiology of Vitamin A Deficiency and Depletion
171
ModelBased Compartmental Analysis of Retinol Kinetics
185
Molecular and Cell Biology
205
Retinoic Acid Receptors and the Regulation of Gene
223
Binding Affinities of Retinoids to Their Binding Proteins
237
Differential Expression of Cytoplasmic Retinoic Acid
249
Selective Synthetic Ligands for Nuclear Retinoic Acid
261
Identification of Thymosin Beta10 as a Developmentally
269
Retinoid Status Skin Tumor Formation and Differentiation
299
Pharmacological Studies on Fenretinide in Breast Cancer
473
A Novel Arotinoid with Anticancer Activity
491
Pharmacology of Retinoids in Models of Photodamage
507
Retinoids and Carotenoids Are Peroxyl Radical Scavengers
525
Analytics and Pharmacokinetics
551
Comparative Distribution of Retinol and Alltrans Retinoic
569
Fluorescent and Photoaffinity Labeling Probes for Retinoic
585
Teratogenesis Transplacental Pharmacokinetics
599
An Update
617
Index
635
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