John M. Coffin, Stephen H. Hughes, Harold Varmus
Cold Spring Harbor Laboratory Press, 1997 - Medical - 843 pages
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biomechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphona have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This volume aims to satisfy that need.
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Retroviral Virions and Genomes
Viral Entry and Receptors
Reverse Transcriptase and the Generation of Retroviral DNA
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Acad activity amino acid amphotropic ASLV assay avian binding Biol cell lines cellular chromosome cleavage cloned complex cytoplasm deletion dimer disease DNA synthesis domain ecotropic elements encoded endogenous env gene Env proteins envelope enzyme function fusion Gag proteins gene expression genetic genome genomic RNA glycoprotein Goff host human immunodeficiency virus identified immunodeficiency virus type induce insertion integrase integration interactions intron lymphoma mammary mechanism mediated membrane mice MMTV Mo-MLV molecular molecules Moloney murine leukemia mouse mRNA murine leukemia virus mutations Natl Nucleic Acids nucleotide oncogene packaging particles peptide poly(A precursor primer Proc processing protease protein proviruses quences receptor recombination region residues retroelements retrotransposons retroviral vectors retroviruses reverse transcriptase RNA polymerase RNase H role Rous sarcoma virus sequences specific splicing structure T-cell target tion trans transcription factors tRNA tumor Varmus viral DNA virion Virol Virology viruses vitro vivo