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Application of Toxicokinetic Models
Effects of Xenobiotics on Microsomal Mixedfunction
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activity acute administration aerosol aflatoxin agents antibody antigen assay assessment behavioral behavioral toxicology bioassay biological cage cancer carcinogenesis carcinogenic cells chromosome compound concentrations contamination cytochrome P450 damage deposition detect determine diet dogs drug effects environment environmental enzyme evaluation examined excretion experimental exposure females function genetic guidelines hamster hazard Health human immune response increased induced infection inhalation irritation laboratory animals large numbers lesions liver lung lymphocytes macrophages male mammalian mammary tumors measured metabolism metabolites method mice microsomal monkey mouse mutagens mutations National Toxicology Program necropsy Newberne nitrosamines numbers of animals OECD organs particles Pathology pharmacokinetics Pharmacol plasma porphyria potential procedures produced protocol rabbit rats regulatory Research respiratory tract risk rodents safety screening selected sensitivity skin species substance Table tapetum lucidum techniques teratology test chemical tissues toxicity toxicity testing Toxicol tumors virus vitro vivo xenobiotics