Schistosomiasis: The St Lucia Project
Schistosomiasis is a disease affecting over 200 million people in developing countries. It is caused by worms that need particular species of fresh water snails for completing their life cycle, and developments in Third World countries have spread and increased the severity of the disease. Dr Jordan describes a 15 year study on St Lucia, a mountainous Caribbean Island where isolated valleys provided ideal field laboratories for comparing the effects on transmission, the advantages and disadvantages of intensive snail control, environmental improvement (providing villages with water), and chemotherapy with newly available drugs. The project was staffed by a multidisciplinary team and their intensive programme led to successful control. This book describes the investigation, fully and readably. It will be valuable to all who work in the fields of tropical medicine, parasitology, epidemiology, community and environmental health, and vital to workers on schistosomiasis control in developing countries.
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The island of St Lucia
Snail intermediate hosts and schistosomiasis in
The strategic plan and methods of investigation
Untreated comparison areas
Chemotherapy in control
Control of the intermediate snail host
Fond St Jacques
Summary and recommendations
Comparison of control strategies
Immunological studies Dr D G Colley
Balanced incomplete block design for studying water contact
adults age groups amongst banana drains Barnish C/R ratio Calypso cercariae chemical chemotherapy compared comparison area contamination cost Cul de Sac dose egg excretion egg output endemic exam exposure Fond St Fond St Jacques found infected geometric mean glabrata granifera habitats hepatosplenomegaly high transmission areas hycanthone incidence increased index sites infected snails infection rates intensity of infection investigated island laboratory latrines laundry and shower liver low transmission areas mansoni mansoni infection Marquis valley marsh mg/kg miracidia molluscicide months negative niclosamide oxamniquine parasitological patients persons praziquantel pre-control Prentice prevalence and intensity programme rainfall Ravine reduced rH rH Richefond valley river Roseau valley routine focal Sac valley samples schistosomal schistosomiasis sentinel snail settlements shower units shown in Table side effects slow-release snail populations Soufriere splenomegaly St Lucia standpipe stool examination stream Sturrock survey TBTO treated treatment villages water contact water supplies
Page 410 - Immune responses during human schistosomiasis mansoni. I. In vitro lymphocyte blastogenic responses to heterogeneous antigenic preparations from schistosome eggs, worms and cercariae. Int.
Page 407 - KS WARREN. 1964. Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Trans. Roy. Soc. Trop. Med. Hyg. 58: 53-57.
Page 412 - Changing host granulomatous response to schistosome eggs at different stages of infection with Schistosoma mansoni. Am. J. Pathol., 52: 369-377.