Schizophrenia

Front Cover
Daniel R. Weinberger, Paul Harrison
John Wiley & Sons, Jul 13, 2011 - Medical - 736 pages
1 Review
Schizophrenia is one of the most complex and disabling diseases to affect mankind.   Relatively little is known about its nature and its origins, and available treatments are inadequate for most patients. As a result, there are inevitable controversies about what causes it, how to diagnose it, and how best to treat it.   However, in the past decade, there has been an explosion of new research, with dramatic discoveries involving genetic etiology and epidemiological risk factors.  There has also been a catalog of new drugs coming to market, and controversy about the relative advantages and disadvantages of newer compared with older therapies.   In addition, developing technologies in genomics, molecular biology and neuroimaging provide streams of new information.

This book represents a definitive, essential, and up-to-date reference text on schizophrenia. It extensively and critically digests and clarifies recent advances and places them within a clinical context.  The Editors (one American and one British), highly respected clinical psychiatrists and researchers and acknowledged experts on schizophrenia, have again assembled an outstanding group of contributors from the USA, UK, Europe and Australia, It will be of value to practising psychiatrists and to trainees, as well as to clinical and neuroscience researchers interested in keeping up with this field or coming into it.

The book consists of four sections:   descriptive aspects, biological aspects, physical treatments, and psychological and social aspects.   It reviews the theoretical controversies over symptomatology, classification and aetiology (particularly pertinent as DSM-V is being developed), the relationship of schizophrenia to the other psychoses, the significance of positive and negative symptoms and pre-morbid personality. It describes a variety of approaches to integrating the vast research data about schizophrenia, including neurodevelopmental, genetic, pharmacological, brain imaging and psychological findings. The biological treatment section reviews the comparative efficacy of various drugs, the management of drug-resistant patients and both neurological and metabolic complications. The final section looks at psychological therapies, social outcomes, and the economics of schizophrenia. 

Highly Commended in the Psychiatry section of the 2012 BMA Book Awards.

 

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what a terrible waste of time.

Contents

Contributors
1895
Preface to the 3rd Edition
1901
symptomatic presentation
1914
Child and adolescent schizophrenia
1937
Lateonset schizophrenia
1972
Acknowledgement
1987
Psychometric assessment
1994
The prodrome of schizophrenia
1762
Dopamine and schizophrenia
1760
Contributions of glutamate and GABA systems to the neurobiology
1789
Animal models of schizophrenia
1835
Pharmacology and neuroscience of antipsychotic drugs
1866
antipsychotics
1892
Principles of pharmacological treatment in schizophrenia
1915
Comparative efficacy and effectiveness in the drug treatment
1930
Conclusions
1945

Course and outcome
1782
Social course of schizophrenia
1799
Conclusions
1812
their character and role
1840
Biological Aspects
1871
the epidemiological horizon
1903
Environmental risk factors for schizophrenia
1961
Classical genetic studies of schizophrenia
1990
Genetic associations in schizophrenia
2026
Intermediate phenotypes in genetic studies of schizophrenia
2055
Electrophysiology of schizophrenia
2086
Conclusions
2106
Functional brain imaging in schizophrenia
1672
Neuropathology of schizophrenia
1700
Neurodevelopmental origins of schizophrenia
1732
Neurological complications of antipsychotic drugs
1980
Cerebrovascular events
1995
Metabolic adverse effects associated with antipsychotic medications
2005
Schizophrenia and psychosocial stresses
2037
Life events and schizophrenia
2040
Mental health services for patients with schizophrenia
2072
Specialist teams or specialist functions?
2087
Violence and schizophrenia
2100
Homelessness
2117
Psychological treatment of psychosis
2134
Comorbid disorders
2154
Costeffectiveness
2168
Index
2182
Copyright

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About the author (2011)

Daniel R. Weinberger, Director: Genes, Cognition and Psychosis Program, National Institute of Mental  Health, National Institute of Health, Bethesda, USA

Paul J. Harrison, University Department of Psychiatry, Warneford Hospital, Oxford, UK

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