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Overview of validation process
Chemicals selection for validation studies
4 other sections not shown
acute toxicity altemative test animal testing approach assay assessment process Balb/c calibration carcinogenicity cell culture chemical class chemicals selected chemicals which produce concem correlation criteria cytotoxicity cytotoxicity tests deﬁne defmed determine discussion dose Draize eye test Draize test enzyme established exposure exposure-response relationship extrapolation factors false negatives false positives ﬁrst hepatocyte hepatotoxicity human toxicity identiﬁed important incidence of false inﬂuence Intralaboratory Assessment intrinsic cellular toxicity mechanisms mechanistic metabolism neutral red non-toxic objective ocular irritation testing pathology positives and false possible problems quantal reference classiﬁcation regulatory reliability replace risk assessment scientiﬁc screening purposes screening tests secondary laboratories signiﬁcant sodium chloride speciﬁc sufﬁcient condition target organ teratogenicity test battery test chemicals testing data testing protocols tissue toxic chemicals toxic effects toxicity testing systems toxicokinetics toxicological toxicological endpoint toxicological evaluation toxicological responses validation process validation project validation study vitro systems vitro test systems vitro toxicity testing vivo testing whole-animal