Scleroderma: From Pathogenesis to Comprehensive Management

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Springer Science & Business Media, Dec 21, 2011 - Medical - 689 pages

This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.

 

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Contents

Historical Perspective
3
Therapeutic Evolution A Professors View
7
Epidemiology Genetics and Classification
13
Overview Epidemiology Genetics and Classification
14
Epidemiology and Environmental Risk Factors
17
Genetic Factors
29
Disease Subsets in Clinical Practice
45
Evolving Concepts of Diagnosis and Classification
53
Cardiac Involvement
373
Erectile Dysfunction
395
Pulmonary Manifestations and Management
399
Overview Pulmonary Manifestations and Management
401
Clinical Assessment of Lung Disease
403
Computerized Tomography of Interstitial Lung Disease
415
Treatment of Interstitial Lung Disease
421
Clinical Assessment of Pulmonary Hypertension
429

Disease Classification Using Molecular Signatures
70
Scleroderma in Children
84
Juvenile Localized Scleroderma
85
Juvenile Systemic Sclerosis
93
Other Fibrosing Skin Conditions
101
Scleroderma Mimics
103
Localized Forms of Scleroderma
113
Nephrogenic Systemic Fibrosis
137
Pathogenetic Basis
160
Overview Pathogenesis Integrated
163
Immunological Mechanisms
165
Innate Immunity
191
Autoantibodies in Pathogenesis
199
The Clinical Aspects of Autoantibodies
209
Mechanisms of Vascular Disease
227
Vascular Biomarkers
247
Mechanism of Fibrosis
255
Fibrosis Insights from the Stiff Skin Syndrome
267
Biomarkers of Fibrosis
283
Overview of Animal Models
291
Cardiovascular Manifestations and Management
310
Overview Cardiovascular Manifestations and Management
311
Raynauds Phenomenon
313
Nailfold Capillaroscopy
331
Systemic Vascular Disease
347
Scleroderma Renal Crisis
361
Treatment of Pulmonary Hypertension
437
Complex Challenges of Pulmonary Hypertension
447
Gastrointestinal Manifestations and Management
461
Overview Gastrointestinal Manifestations and Management
463
Upper Gastrointestinal Tract
471
Small and Large Intestinal Involvement
485
Skin Musculoskeletal and Other Complications
502
Evaluation and Management of Skin Disease
503
Skeletal Muscle Involvement
525
Tendons Joints and Bone
531
Pregnancy
547
Overlooked Manifestations
559
DiseaseModifying Strategies
570
Principles of Management
571
Immunomodulatory Therapies
577
CellBased Therapies
591
Investigative Approaches to Drug Therapy
603
Complementary and Alternate Medicine Approaches
615
Physical and Occupational Therapy
629
Evaluation and Management of Psychosocial Issues
641
Outcome Assessment
650
Issues in Clinical Trial Design
651
Measuring Disease Activity and Outcomes in Clinical trials
661
PatientReported Outcomes
673
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