This book is concerned with the biosynthesis, biological activity, and ecological significance of secondary metabolites (natural products).These include alcaloids such as morphine, steroids like cholesterol, and antibiotics like the penicillins. The author considers each of the major classes of secondary metabolites according to the basic 'building blocks' from which they are derived and highlights the pharmacological and toxicological properties of compounds found in insects, plants, and microorganisms. The final chapter explores the possible ecological significance of these products. The second edition incorporates new material on the isolation and characterization of the enzymes of secondary metabolism and on the new NMR techniques which have revolutionized the elucidation of biosynthetic pathways. The book is important reading for advanced undergraduates and graduates in chemistry, biochemistry, and botany, as well as researchers in the pharmaceutical industry.
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METABOLITES DERIVED FROM SHIKIMIC ACID
THE SECONDARY METABOLISM OF AMINO ACIDS
METABOLITES OF MIXED BIOSYNTHETIC ORIGIN
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acetyl-SCoA active alkaloids alkylation amino acids analogues antibiotics aromatic biogenesis biogenetic biological biosynthesis biosynthetic pathway C2 units carbon atoms cardenolides CH2OH Chapter Chem chemical chemistry cholesterol cinnamic acid cleavage CO,H CO2H cofactor compounds contain COSCoA coupling cyclization decarboxylation degradation derived from acetate derived from shikimate deuterium DMAPP enzyme ester example fatty acids flavonoids fungal fungus geranyl higher plants hormones hydrogen hydroxylation incorporated insects interactions intermediacy intermediate involved isolated isoprene isoprenoids isotopically known labelling pattern lysine metabolic pathways metabolites derived methyl groups mevalonate mode molecule monoterpenes NADPH Natural Product Reports nucleophilic occur OH OH organisms oxidative oxygen pathway shown phenols phenylalanine pheromones polyketide potent precursor probably produced prostaglandins pyrophosphate pyruvate reactions reduction ring S-adenosyl methionine secondary metabolites sesquiterpenes shikimic acid shown in eqn shown in Fig side-chain skeletal types skeleton species spectrum steroid structural sub-unit substrate synthesized terpenes toxic tracer tryptophan tyrosine utilized vitamin