Signalling Molecules as Targets in Cancer Therapy

Front Cover
This book presents state-of-the-art information on the molecules of cell signalling pathways that represent actual or future targets for cancer therapy. By giving an update of the most promising approaches in this rapidly evolving field, the book contributes to the translation of the recent advances in the knowledge of intracellular signalling into the generation of innovative biomolecules as specific tools to target the most promising tumour-specific candidates. The book begins logically with the molecules first encountered along the signalling pathways, the membrane receptors for growth factors (Part I). Next, Part II presents several examples of intracellular molecular targets that are situated one step beyond in the pathways, while Part III addresses the difficult task of tuning the delicate balance between cell death and survival. In Part IV, the reader is taken into the practical problems raised by the therapy of specific cancers (glioma, childhood leukaemia), and into an original strategy from the field of nuclear medicine with the potential to generate innovative molecular-targeted cancer therapies.
 

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Contents

Targeting Receptor Tyrosine Kinase Mutations in Cancer
3
The RET ProtoOncogene A Valuable Target for Thyroid Cancer Therapy
21
Inhibitors of HERErbB Receptors Biological Bases and Clinical Applications
35
Targeting Intracellular Molecules
67
Phosphatases as Promising Targets for Cancer Therapy
69
Targeting the mTOR Pathway for Cancer Therapy
87
Targeting MAP Kinase Signaling Pathways for the Treatment of Cancer
109
Targeting Apoptosis
141
Cell DeathBased Therapy
143
Part IV Strategies for Drug Development and Delivery
163
Signaling Molecules and Therapeutic Targets in Gliomas
165
Identifying and Targeting Genes Involved in Childhood Leukemia
191
Receptor Binding Peptides for Receptor Mediated Endoradiotherapy in Oncology
215
Index
227
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