Signaling Pathways in Liver Diseases

Front Cover
Pierre-Alain Clavien, Jean-Francois Dufour
John Wiley & Sons, Aug 31, 2015 - Medical - 520 pages

Signaling Pathways in Liver Diseases, Third Edition again provides hepatologists and hepatology researchers with an expert overview of the complex and novel cellular/extracellular signaling pathways in the liver, and their role in liver diseases. The last few years have seen a great number of developments in this field, which in turn have led to new opportunities for innovative treatments; however, the intricacy of these pathways and their interactions continue to provide a real challenge for clinicians. This outstanding book compiles the emerging knowledge into a single expert resource, cataloguing and organizing it into an accessible and understandable format.

With increased focus on the comprehension of cellular mechanisms involved in steatohepatitis, cirrhosis, and liver tumors, which has led to changes in the management of these diseases, this new edition also sees the introduction of exciting new chapters on key emerging areas such as:

  • Autophagy
  • Notch Pathway
  • P13K/PTEN Signaling in Liver Diseases
  • Sirtuins
  • Hepcidin and Iron
  • Epigenetic Regulation of Hepatic Stellate Cells and Liver Fibrosis
  • Oxidative Stress and Signaling in the Liver.

Professors Dufour and Clavien have assembled an all-star cast of chapter authors, each of whom has provided clear and appropriate illustrations to reinforce the text, with a key points box offering a concise and handy summary. Self-assessment questions and answers allow the reader to test their own knowledge.

Signaling Pathways in Liver Disease, Third Edition is the perfect educational and reference tool to bridge the information exchange between the laboratory, the clinical ward, and the operating room, and an essential tool for the modern-day hepatologist.


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Signaling in hepatocellular carcinoma 435 Adam Pennycuick and Augusto Villanueva 35 Oxidative stress and signaling in the liver 469 Mitchell R ...
Derek A Mann Department of Cell Physiology and Metabolism Faculty
Bilon Khambu
Division of Gastroenterology and Hepatology Mayo Clinic Belo Horizonte Brazil
Eoin McDonnell David A Rudnick
Mitchell R McGill
Division of Gastroenterology and Hepatology
Hepatic sinusoidal endothelial cells 73 21 PI3KPTEN signaling in liver diseases
Extracellular matrix 85 22 mTOR signaling in liver disease
Immune cell communication in liver disease energy metabolism
Ricky H Boghal B F Stephenson 24 NFκB
Extracellular vesicle RNA in liver disease 130 25 cJun NH2terminal kinases in liver diseases
Endoplasmic reticulum stress in nonalcoholic 26 p53
Autophagy 151 27 Sirtuins
and regeneration 166 28 Bile acids and their receptors

List of Contributors vii 16 Interferon signaling
JeanFrançois Dufour and Joachim C Mertens 17 Endocannabinoid signaling in liver pathologies
Signaling pathways in biliary epithelial cells 15 Bostjan Humar and Nasser Semmo
Stellate cells 34 19 Hedgehog signaling in the liver
Kupffer cells 61 20 Notch pathway
Hiroyuki Nojima and Alex B Lentsch 29 Hepcidin and iron
Metabolic regulation of liver regeneration 174 Chiara Vecchi and Antonello Pietrangelo
FasFasL 203 and liver fibrosis
Interplay between hepatitis B virus and innate immune signaling pathways 448 Answers to MCQs 479 Index 483

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About the author (2015)

Professor Jean-François Dufour, MD, PhD, Chief, Department of Clinical Pharmacology, University Clinic Visceral Surgery and Medicine, Bern, Switzerland.
Professor Dufour is on the governing board of the European Association for the Study of the Liver (EASL). He also serves as Associate Editor for the Wiley journal Liver International and is on the editorial board for the following journals: Journal of Hepatology; Clinical Science; World Journal of Gastroenterology

Professor Pierre-Alain Clavien, MD, PhD, FACS, FRCS (Eng), FRCS (Ed), Professor and Chairman, Department of Surgery. Head, Division of Visceral & Transplantation Surgery, University Hospital Zurich, Switzerland.
Professor Clavien is a world-wide renowned surgeon-scientist, currently professor and chairman of the Department of Surgery in Zurich, Switzerland. His areas of research include organ preservation, liver ischemia-reperfusion injury and regeneration, and pathogenesis of cancer, as well as outcome research. He received many competitive grants and awards, including one of the most prestigious prices for scientific research, the Otto Naegeli Award.

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