Peter M. Elias, Kenneth R. Feingold
Taylor & Francis, 2006 - Medical - 612 pages
A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatitis, psoriasis, and ichthyosis.
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A Brief History of How the Dead Stratum Corneum
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activity amino acids atopic dermatitis barrier disruption barrier function barrier recovery basal biochemical Biol Chem calcium calcium gradient Cell Biol ceramides CHOL cholesterol cholesterol sulfate corneocytes corneodesmosomes cornified envelope cutaneous cytokines decreased desmosomes desquamation disease domain Downing DT Elias PM enzyme epidermal epidermal barrier epidermal differentiation epidermal permeability barrier epithelia expression extracellular fatty acids Feingold filaggrin formation gene GlcCer glucosylceramide granular homeostasis human epidermis human keratinocytes human SC human skin ichthyosis IL-1 alpha increased intercellular interleukin-1 Invest Dermatol 2003 involucrin keratin keratinocytes lamellar bodies layers levels lipid lipid processing Lipid Res loricrin mammalian membrane Menon GK metabolic mice molecular mouse mRNA murine mutations normal phase profilaggrin protease protein receptor regulation role SC lipid secretion serine skin barrier sphingolipid sphingomyelin sphingosine Steinert PM stratum corneum stratum corneum lipid structure studies synthesis TEWL tight junction tion tissue transglutaminase trichohyalin vitro vivo Wertz PW Williams ML