State of the Art of Hepatology: Molecular and Cell Biology

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Springer Science & Business Media, Jun 30, 2004 - Medical - 234 pages

This book is the proceedings of the Falk Symposium No. 138 on "State of the Art of Hepatology: Molecular and Cell Biology" (part of the XII International Falk Liver Week 2003 in honour of Hans Popper’s 100th birthday, held on October 20--11, 2003), and reflects the tremendous advances in the science of hepatology both at the molecular as well as the cellular level.

The book comprises four major sections. In Section I, the basic aspects of liver cell biology are covered, including RNA metabolism, regeneration, transport and metabolic functions, as well as fibrogenesis and malignant transformation. In Section II, the novel field of stem cell plasticity and cell therapy for liver diseases is discussed in detail, including stem cell biology, hepatocyte transdifferentiation from extrahepatic stem cells and their therapeutic use for liver cell repopulation, as well as hepatocyte transplantation. In Section III, novel therapeutic strategies for liver cirrhosis and hepatocellular carcinoma are presented, including the reversal of liver fibrosis, oncolytic biotherapy and different concepts of gene therapy for hepatocellular carcinoma. In Section IV, novel aspects of gene therapy and prevention of liver diseases are addressed, including small interfering RNAs, ribozymes, antisense oligonucleotides, as well as DNA vaccination.

An international faculty of outstanding scientists from different research areas presents the state of the art on these most important aspects of hepatology and their perspectives for future developments. Molecular and cell biology are at the very centre of research developments in modern hepatology and are of interest and importance to both basic scientists as well as clinicians involved in patient care.

 

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Contents

Extracellular and intracellular control of CD95induced apoptosis in hepatocytes
3
Senescence and chromosomal instability induced by telomere shortening affect liver regeneration and hepatocarcinogenesis
10
Mechanisms of liver regeneration
19
Hepatic transport and metabolism
39
Immune functions of the liver
46
Molecular regulation of hepatic fibrosis
56
Liver cell biology differentiation and malignant transformation
64
Stem cell plasticity and cell therapy
75
DNAbased immunotherapy of hepatocellular carcinoma
122
Suicide gene therapy
135
Gene therapy of liver cancer the present and the future
148
Gene therapy and prevention of liver diseases
169
Hepatic gene transfer
171
Targeted gene repair from RNADNA to singlestranded oligonucleotides
172
Identification of a cellular protein required for hepatitis C virus internal ribosome entry site IRESmediated translation
196
Antisense oligonucleotides
202

Stem cell plasticity studies in the liver
77
Nonhuman primate liver progenitor cells and their transplantation into animal models
89
Biological aspects of hepatocyte transplantation for applications in cell therapy
99
Novel approaches to liver cirrhosis and hepatocellular carcinoma
111
Reversal of liver fibrosis
113
Interfering polypeptides
210
Novel vaccine strategies
214
Index
229
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