Stem Cells: From Mechanisms to Technologies
Advances in stem cell biology and biotechnology have sparked hopes that therapies will soon be available for maladies which were considered incurable before. However, realization of the clinical potential of stem cells will require better understanding of stem cell physiology and the development of advanced technologies for their efficient differentiation in medically relevant quantities. Resolving these issues necessitates synergistic approaches from multiple fields. Systems biology can be employed to dissect the mechanisms regulating the genome and proteome of stem cells during self-renewal and commitment. Microfluidic platforms can be used to recreate aspects of the stem cell niche and obtain a better understanding of the interactions among stem cells and with their environment. The milieu of stem cells and their progeny can be shaped with appropriately designed biomaterials for the engineering of tissues to replace, reconstitute or regenerate damaged organs. To that end, enabling bioreactor technologies will be necessary for the generation of large quantities of stem cells and their derivatives in a robust and cost-efficient manner. This book invites world-renowned experts in the above fields to discuss the latest advances in their respective areas and to provide insights on the future challenges and achievements in the area of stem cells.
What people are saying - Write a review
We haven't found any reviews in the usual places.
Other editions - View all
activation adhesion angiogenesis apoptosis attractor Biol biological biomaterials bioreactor Biotechnol bone marrow brain Buzanska cell culture cell differentiation cell lines cell types cellular cord blood cells cytokines deﬁned developmental downregulated efﬁcient embryonic stem cells ESCs expression pattern extracellular FGF2 FGFR1 ﬁbroblast growth factor Figure ﬁrst functional growth factor hematopoietic stem cells hESCs hiPSCs HUCB HUCB-NSC human embryonic stem human umbilical cord hydrogels identiﬁed induced pluripotent stem inﬂuence INFS interactions lineage markers mechanisms megakaryocytes mESCs mesenchymal stem cells microcarriers modiﬁed modules molecular molecules mouse Nanog neural stem cells neuronal neuronal differentiation nuclear FGFR1 ofthe ORMOSIL oxygen parameters pathway pluripotent stem cells potential proﬁle progenitor cells proliferation promote protein receptor regulation reprogramming RSK1 scaffolds self—renewal signaling signiﬁcant Sox2 speciﬁc Stachowiak studies surface tissue engineering transcription factors transfected transplantation umbilical cord blood upregulated vascular vectors vitro vivo